TY  - JOUR
AU  - Wragg, KM
AU  - Tan, H-X
AU  - Kristensen, AB
AU  - Nguyen-Robertson, C
AU  - Kelleher, AD
AU  - Parsons, MS
AU  - Wheatley, AK
AU  - Berzins, SP
AU  - Pellicci, DG
AU  - Kent, SJ
AU  - Juno, JA
Y2  - 2020/11/27
Y1  - 2020/06/16
SN  - 2211-1247
UR  - http://hdl.handle.net/11343/252446
AB  - Vδ2+ T cells play a critical role in immunity to micro-organisms and cancer but exhibit substantial heterogeneity in humans. Here, we demonstrate that CD26 and CD94 define transcriptionally, phenotypically, and functionally distinct Vδ2+ T cell subsets. Despite distinct antigen specificities, CD26hiCD94lo Vδ2+ cells exhibit substantial similarities to CD26hi mucosal-associated invariant T (MAIT) cells, although CD26- Vδ2+ cells exhibit cytotoxic, effector-like profiles. At birth, the Vδ2+Vγ9+ population is dominated by CD26hiCD94lo cells; during adolescence and adulthood, Vδ2+ cells acquire CD94/NKG2A expression and the relative frequency of the CD26hiCD94lo subset declines. Critically, exposure of the CD26hiCD94lo subset to phosphoantigen in the context of interleukin-23 (IL-23) and CD26 engagement drives the acquisition of a cytotoxic program and concurrent loss of the MAIT cell-like phenotype. The ability to modulate the cytotoxic potential of CD26hiCD94lo Vδ2+ cells, combined with their adenosine-binding capacity, may make them ideal targets for immunotherapeutic expansion and adoptive transfer.
LA  - English
PB  - CELL PRESS
T1  - High CD26 and Low CD94 Expression Identifies an IL-23 Responsive V delta 2(+) T Cell Subset with a MAIT Cell-like Transcriptional Profile
DO  - 10.1016/j.celrep.2020.107773
IS  - Cell Reports
VL  - 31
IS  - 11
L1  - /bitstream/handle/11343/252446/PIIS2211124720307531.pdf?sequence=1&isAllowed=y
ER  -