TY  - JOUR
AU  - Chen, M
AU  - Cai, J
AU  - Davies, MR
AU  - Li, Y
AU  - Zhang, C
AU  - Yao, W
AU  - Kong, D
AU  - Pan, H
AU  - Zhang, X
AU  - Zeng, M
AU  - Chen, M
Y2  - 2020/11/27
Y1  - 2020/09/01
SN  - 1201-9712
UR  - http://hdl.handle.net/11343/252469
AB  - OBJECTIVE: Scarlet fever epidemics caused by group A Streptococcus (GAS) have been ongoing in China since 2011. However, limited data are available on the dynamic molecular characterizations of the epidemic strains. METHOD: Epidemiological data of scarlet fever in Shanghai were obtained from the National Notifiable Infectious Disease Surveillance System. Throat swabs of patients with scarlet fever and asymptomatic school-age children were cultured. Illumina sequencing was performed on 39emm1 isolates. RESULTS: The annual incidence of scarlet fever was 7.5-19.4/100,000 persons in Shanghai during 2011-2015, with an average GAS carriage rate being 7.6% in school-age children. The proportion ofemm1 GAS strains increased from 3.8% in 2011 to 48.6% in 2014; they harbored a superantigen profile similar to emm12 isolates, except for the speA gene. Two predominant clones, SH001-emm12, and SH002-emm1, circulated in 66.9% of scarlet fever cases and 44.8% of carriers. Genomic analysis showed emm1 isolates throughout China constituted distinct clades, enriched by the presence of mobile genetic elements carrying the multidrug-resistant determinants ermB and tetM and virulence genes speA, speC, and spd1. CONCLUSION: A significant increase in the proportion ofemm1 strains occurred in the GAS population, causing scarlet fever in China. Ongoing surveillance is warranted to monitor the dynamic changes of GAS clones.
LA  - English
PB  - ELSEVIER SCI LTD
T1  - Increase of emm1 isolates among group A Streptococcus strains causing scarlet fever in Shanghai, China
DO  - 10.1016/j.ijid.2020.06.053
IS  - International Journal of Infectious Diseases
VL  - 98
SP  - 305-314
L1  - /bitstream/handle/11343/252469/PIIS1201971220304884.pdf?sequence=1&isAllowed=y
ER  -