TY  - JOUR
AU  - Gurholt, TP
AU  - Lonning, V
AU  - Nerland, S
AU  - Jorgensen, KN
AU  - Haukvik, UK
AU  - Alloza, C
AU  - Arango, C
AU  - Barth, C
AU  - Bearden, CE
AU  - Berk, M
AU  - Bohman, H
AU  - Dandash, O
AU  - Diaz-Caneja, CM
AU  - Edbom, CT
AU  - van Erp, TGM
AU  - Fett, A-KJ
AU  - Frangou, S
AU  - Goldstein, BI
AU  - Grigorian, A
AU  - Jahanshad, N
AU  - James, AC
AU  - Janssen, J
AU  - Johannessen, C
AU  - Karlsgodt, KH
AU  - Kempton, MJ
AU  - Kochunov, P
AU  - Krabbendam, L
AU  - Kyriakopoulos, M
AU  - Lundberg, M
AU  - MacIntosh, BJ
AU  - Rund, BR
AU  - Smelror, RE
AU  - Sultan, A
AU  - Tamnes, CK
AU  - Thomopoulos, SI
AU  - Vajdi, A
AU  - Wedervang-Resell, K
AU  - Myhre, AM
AU  - Andreassen, OA
AU  - Thompson, PM
AU  - Agartz, I
Y2  - 2020/11/27
Y1  - 2020/10/05
SN  - 1065-9471
UR  - http://hdl.handle.net/11343/252605
AB  - Early-onset psychosis disorders are serious mental disorders arising before the age of 18 years. Here, we investigate the largest neuroimaging dataset, to date, of patients with early-onset psychosis and healthy controls for differences in intracranial and subcortical brain volumes. The sample included 263 patients with early-onset psychosis (mean age: 16.4 ± 1.4 years, mean illness duration: 1.5 ± 1.4 years, 39.2% female) and 359 healthy controls (mean age: 15.9 ± 1.7 years, 45.4% female) with magnetic resonance imaging data, pooled from 11 clinical cohorts. Patients were diagnosed with early-onset schizophrenia (n = 183), affective psychosis (n = 39), or other psychotic disorders (n = 41). We used linear mixed-effects models to investigate differences in intracranial and subcortical volumes across the patient sample, diagnostic subgroup and antipsychotic medication, relative to controls. We observed significantly lower intracranial (Cohen's d = -0.39) and hippocampal (d = -0.25) volumes, and higher caudate (d = 0.25) and pallidum (d = 0.24) volumes in patients relative to controls. Intracranial volume was lower in both early-onset schizophrenia (d = -0.34) and affective psychosis (d = -0.42), and early-onset schizophrenia showed lower hippocampal (d = -0.24) and higher pallidum (d = 0.29) volumes. Patients who were currently treated with antipsychotic medication (n = 193) had significantly lower intracranial volume (d = -0.42). The findings demonstrate a similar pattern of brain alterations in early-onset psychosis as previously reported in adult psychosis, but with notably low intracranial volume. The low intracranial volume suggests disrupted neurodevelopment in adolescent early-onset psychosis.
LA  - English
PB  - WILEY
T1  - Intracranial and subcortical volumes in adolescents withearly-onsetpsychosis: A multisitemega-analysisfrom theENIGMAconsortium
DO  - 10.1002/hbm.25212
IS  - Human Brain Mapping
L1  - /bitstream/handle/11343/252605/hbm.25212.pdf?sequence=1&isAllowed=y
ER  -