TY  - JOUR
AU  - Guerit, F
AU  - Marozeau, J
AU  - Epp, B
AU  - Carlyon, RP
Y2  - 2020/12/09
Y1  - 2020/08/24
SN  - 1438-7573
UR  - http://hdl.handle.net/11343/252909
AB  - The effect of the relative timing between pairs of same-polarity monophasic pulses has been studied extensively in single-neuron animal studies and has revealed fundamental properties of the neurons. For human cochlear implant listeners, the requirement to use charge-balanced stimulation and the typical use of symmetric, biphasic pulses limits such measures, because currents of opposite polarities interact at the level of the neural membrane. Here, we propose a paradigm to study same-polarity summation of currents while keeping the stimulation charge-balanced within a short time window. We used pairs of mirrored pseudo-monophasic pulses (a long-low phase followed by a short-high phase for the first pulse and a short-high phase followed by a long-low phase for the second pulse). We assumed that most of the excitation would stem from the two adjacent short-high phases, which had the same polarity. The inter-pulse interval between the short-high phases was varied from 0 to 345 μs. The inter-pulse interval had a significant effect on the perceived loudness, and this effect was consistent with both passive (membrane-related) and active (ion-channel-related) neuronal mechanisms contributing to facilitation. Furthermore, the effect of interval interacted with the polarity of the pulse pairs. At threshold, there was an effect of polarity, but, surprisingly, no effect of interval nor an interaction between the two factors. We discuss possible peripheral origins of these results.
LA  - English
PB  - Springer Verlag
T1  - Effect of the Relative Timing between Same-Polarity Pulses on Thresholds and Loudness in Cochlear Implant Users
DO  - 10.1007/s10162-020-00767-y
IS  - JARO: Journal of the Association for Research in Otolaryngology
VL  - 21
IS  - 6
SP  - 497-510
L1  - /bitstream/handle/11343/252909/PMC7644659.pdf?sequence=1&isAllowed=y
ER  -