TY  - JOUR
AU  - Hicks, S
AU  - Pohl, K
AU  - Neeman, T
AU  - McNamara, H
AU  - Parsons, K
AU  - He, J-S
AU  - Ali, S
AU  - Nazir, S
AU  - Rowntree, L
AU  - Nguyen, T
AU  - Kedzierska, K
AU  - Doolan, D
AU  - Vinueas, C
AU  - Cook, M
AU  - Coatsworth, N
AU  - Myles, P
AU  - Kurth, F
AU  - Sander, L
AU  - Mann, G
AU  - Gruen, R
AU  - George, A
AU  - Gardiner, E
AU  - Cockburn, I
AU  - the SARS-CoV-2 Testing in Elective Surgery Collaborators
Y2  - 2020/12/09
Y1  - 2020/09/14
UR  - http://hdl.handle.net/11343/253073
AB  - Estimates of seroprevalence of SARS-CoV-2 antibodies have been hampered by inadequate assay sensitivity and specificity. Using an ELISA-based approach to that combines data about IgG responses to both the Nucleocapsid and Spike-receptor binding domain antigens, we show that near-optimal sensitivity and specificity can be achieved. We used this assay to assess the frequency of virus-specific antibodies in a cohort of elective surgery patients in Australia and estimated seroprevalence in Australia to be 0.28% (0 to 0.72%). These data confirm the low level of transmission of SARS-CoV-2 in Australia before July 2020 and validate the specificity of our assay.
PB  - Cold Spring Harbor Laboratory
T1  - A dual antigen ELISA allows the assessment of SARS-CoV-2 antibody seroprevalence in a low transmission setting
DO  - 10.1101/2020.09.09.20191031
L1  - /bitstream/handle/11343/253073/EMS95138-pdf.pdf?sequence=1&isAllowed=y
ER  -