TY  - JOUR
AU  - Ng, SP
AU  - Tan, J
AU  - Osbourne, G
AU  - Williams, L
AU  - Bressel, MAB
AU  - Hicks, RJ
AU  - Lau, EWF
AU  - Chu, J
AU  - Ngan, SYK
AU  - Leong, T
Y2  - 2020/12/10
Y1  - 2017/02/01
SN  - 2405-6308
UR  - http://hdl.handle.net/11343/253594
AB  - Background: This prospective study aims to determine the impact of PET/CT on radiotherapy planning and outcomes in patients with oesophageal cancer. Methods: All patients underwent PET/CT scanning in the radiotherapy treatment position, and received treatment planned using the PET/CT dataset. GTV was defined separately on PET/CT (GTV-PET) and CT (GTV-CT) datasets. A corresponding PTV was generated for each patient. Volumetric and spatial analysis quantified the proportion of FDG-avid disease not included in CT-based volumes. Clinical data was collected to determine locoregional control and overall survival rates. Results: 13 (24.1%) of 57 accrued patients had metastatic disease detected on PET. Median follow up was 4 years. FDG-avid disease would have been excluded from GTV-CT in 29 of 38 patients (76%). In 5 patients, FDG-avid disease would have been completely excluded from the PTV-CT. GTV-CT underestimated the cranial and caudal extent of FDG-avid tumour in 14 (36%) and 10 (26%) patients. 4-Year overall survival and locoregional failure free survival were 37% and 65%. Conclusions: PET/CT altered the delineation of tumour volumes when compared to CT alone, and should be considered standard for treatment planning. Although clinical outcomes were not improved with PET/CT planning, it did allow the use of smaller radiotherapy volumes.
LA  - English
PB  - ELSEVIER IRELAND LTD
T1  - Follow up results of a prospective study to evaluate the impact of FDG-PET on CT-based radiotherapy treatment planning for oesophageal cancer
DO  - 10.1016/j.ctro.2017.01.008
IS  - Clinical and Translational Radiation Oncology
VL  - 2
SP  - 76-82
L1  - /bitstream/handle/11343/253594/PMC5893524.pdf?sequence=1&isAllowed=y
ER  -