TY  - JOUR
AU  - Williams, E
AU  - Bond, K
AU  - Isles, N
AU  - Chong, B
AU  - Johnson, D
AU  - Druce, J
AU  - Hoang, T
AU  - Ballard, SA
AU  - Hall, V
AU  - Muhi, S
AU  - Buising, KL
AU  - Lim, S
AU  - Strugnell, D
AU  - Catton, M
AU  - Irving, LB
AU  - Howden, BP
AU  - Bert, E
AU  - Williamson, DA
Y2  - 2020/12/16
Y1  - 2020/09/01
SN  - 0025-729X
UR  - http://hdl.handle.net/11343/254544
AB  - OBJECTIVES: To design and evaluate 3D-printed nasal swabs for collection of samples for SARS-CoV-2 testing. DESIGN: An iterative design process was employed. Laboratory evaluation included in vitro assessment of mock nasopharyngeal samples spiked with two different concentrations of gamma-irradiated SARS-CoV-2. A prospective clinical study compared SARS-CoV-2 and human cellular material recovery by 3D-printed swabs and standard nasopharyngeal swabs. SETTING, PARTICIPANTS: Royal Melbourne Hospital, May 2020. Participants in the clinical evaluation were 50 hospital staff members attending a COVID-19 screening clinic and two inpatients with laboratory-confirmed COVID-19. INTERVENTION: In the clinical evaluation, a flocked nasopharyngeal swab sample was collected with the Copan ESwab and a mid-nasal sample from the other nostril was collected with the 3D-printed swab. RESULTS: In the laboratory evaluation, qualitative agreement with regard to SARS-CoV-2 detection in mock samples collected with 3D-printed swabs and two standard swabs was complete. In the clinical evaluation, qualitative agreement with regard to RNase P detection (a surrogate measure of adequate collection of human cellular material) in samples collected from 50 hospital staff members with standard and 3D-printed swabs was complete. Qualitative agreement with regard to SARS-CoV-2 detection in three pairs of 3D-printed mid-nasal and standard swab samples from two inpatients with laboratory-confirmed SARS-CoV-2 was also complete. CONCLUSIONS: Using 3D-printed swabs to collect nasal samples for SARS-CoV-2 testing is feasible, acceptable to patients and health carers, and convenient.
LA  - English
PB  - WILEY
T1  - Pandemic printing: a novel 3D-printed swab for detecting SARS-CoV-2
DO  - 10.5694/mja2.50726
IS  - Medical Journal of Australia
VL  - 213
IS  - 6
SP  - 276-279
OP  - 1105905
OP  - 1174555
OP  - 1191321
ER  -