TY  - JOUR
AU  - Elander, NO
AU  - Aughton, K
AU  - Ghaneh, P
AU  - Neoptolemos, JP
AU  - Palmer, DH
AU  - Cox, TF
AU  - Campbell, F
AU  - Costello, E
AU  - Halloran, CM
AU  - Mackey, JR
AU  - Scarfe, AG
AU  - Valle, JW
AU  - McDonald, AC
AU  - Carter, R
AU  - Tebbutt, NC
AU  - Goldstein, D
AU  - Shannon, J
AU  - Dervenis, C
AU  - Glimelius, B
AU  - Deakin, M
AU  - Charnley, RM
AU  - Anthoney, A
AU  - Lerch, MM
AU  - Mayerle, J
AU  - Olah, A
AU  - Buchler, MW
AU  - Greenhalf, W
Y2  - 2020/12/17
Y1  - 2018/04/01
SN  - 0007-0920
UR  - http://hdl.handle.net/11343/254731
AB  - BACKGROUND: Deoxycytidylate deaminase (DCTD) and ribonucleotide reductase subunit M1 (RRM1) are potential prognostic and predictive biomarkers for pyrimidine-based chemotherapy in pancreatic adenocarcinoma. METHODS: Immunohistochemical staining of DCTD and RRM1 was performed on tissue microarrays representing tumour samples from 303 patients in European Study Group for Pancreatic Cancer (ESPAC)-randomised adjuvant trials following pancreatic resection, 272 of whom had received gemcitabine or 5-fluorouracil with folinic acid in ESPAC-3(v2), and 31 patients from the combined ESPAC-3(v1) and ESPAC-1 post-operative pure observational groups. RESULTS: Neither log-rank testing on dichotomised strata or Cox proportional hazard regression showed any relationship of DCTD or RRM1 expression levels to survival overall or by treatment group. CONCLUSIONS: Expression of either DCTD or RRM1 was not prognostic or predictive in patients with pancreatic adenocarcinoma who had had post-operative chemotherapy with either gemcitabine or 5-fluorouracil with folinic acid.
LA  - English
PB  - NATURE PUBLISHING GROUP
T1  - Intratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected pancreatic cancer given adjuvant chemotherapy
DO  - 10.1038/s41416-018-0005-1
IS  - British Journal of Cancer
VL  - 118
IS  - 8
SP  - 1084-1088
L1  - /bitstream/handle/11343/254731/PMC5931097.pdf?sequence=1&isAllowed=y
ER  -