TY  - JOUR
AU  - Watts, ME
AU  - Williams, SM
AU  - Nithianantharajah, J
AU  - Claudianos, C
Y2  - 2020/12/17
Y1  - 2018/03/27
SN  - 2311-553X
UR  - http://hdl.handle.net/11343/254758
AB  - Hypoxia-regulated microRNA-210 (miR-210) is a highly conserved microRNA, known to regulate various processes under hypoxic conditions. Previously we found that miR-210 is also involved in honeybee learning and memory, raising the questions of how neural activity may induce hypoxia-regulated genes and how miR-210 may regulate plasticity in more complex mammalian systems. Using a pull-down approach, we identified 620 unique target genes of miR-210 in humans, among which there was a significant enrichment of age-related neurodegenerative pathways, including Huntington's, Alzheimer's, and Parkinson's diseases. We have also validated that miR-210 directly regulates various identified target genes of interest involved with neuronal plasticity, neurodegenerative diseases, and miR-210-associated cancers. This data suggests a potentially novel mechanism for how metabolic changes may couple plasticity to neuronal activity through hypoxia-regulated genes such as miR-210.
LA  - eng
PB  - MDPI AG
T1  - Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways.
DO  - 10.3390/ncrna4020010
IS  - Non-Coding RNA
VL  - 4
IS  - 2
SP  - 10-10
OP  - FT140101327
L1  - /bitstream/handle/11343/254758/PMC6027187.pdf?sequence=1&isAllowed=y
ER  -