TY  - JOUR
AU  - Minlikeeva, AN
AU  - Freudenheim, JL
AU  - Cannioto, RA
AU  - Eng, KH
AU  - Szender, JB
AU  - Mayor, P
AU  - Etter, JL
AU  - Cramer, DW
AU  - Diergaarde, B
AU  - Doherty, JA
AU  - Dörk, T
AU  - Edwards, R
AU  - deFazio, A
AU  - Friel, G
AU  - Goodman, MT
AU  - Hillemanns, P
AU  - Høgdall, E
AU  - Jensen, A
AU  - Jordan, SJ
AU  - Karlan, BY
AU  - Kjær, SK
AU  - Klapdor, R
AU  - Matsuo, K
AU  - Mizuno, M
AU  - Nagle, CM
AU  - Odunsi, K
AU  - Paddock, L
AU  - Rossing, MA
AU  - Schildkraut, JM
AU  - Schmalfeldt, B
AU  - Segal, BH
AU  - Starbuck, K
AU  - Terry, KL
AU  - Webb, PM
AU  - Zsiros, E
AU  - Ness, RB
AU  - Modugno, F
AU  - Bandera, EV
AU  - Chang-Claude, J
AU  - Moysich, KB
Y2  - 2020/12/17
Y1  - 2017/09/26
SN  - 0007-0920
UR  - http://hdl.handle.net/11343/254874
AB  - BACKGROUND: Findings from in vitro studies suggest that increased exposure to thyroid hormones can influence progression of ovarian tumours. However, epidemiologic evidence on this topic is limited. METHODS: We pooled data from 11 studies from the Ovarian Cancer Association Consortium. Using multivariate Cox proportional hazards models, we estimated associations between hyper- and hypothyroidism and medications prescribed for these conditions with 5-year all-cause survival among women diagnosed with invasive ovarian cancer. RESULTS: Overall, there was a nonsignificant association with history of hyperthyroidism (n=160 cases) and mortality (HR=1.22; 95% CI=0.97-1.53). Furthermore, diagnosis of hyperthyroidism within the 5 years before ovarian cancer diagnosis was associated with an increased risk of death (HR=1.94; 95% CI=1.19-3.18). A more modest association was observed with history of hypothyroidism (n=624 cases) and mortality (HR=1.16; 95% CI=1.03-1.31). Neither duration of hypothyroidism nor use of thyroid medications was associated with survival. CONCLUSIONS: In this large study of women with ovarian cancer, we found that recent history of hyperthyroidism and overall history of hypothyroidism were associated with worse 5-year survival.
LA  - eng
PB  - Springer Science and Business Media LLC
T1  - History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report.
DO  - 10.1038/bjc.2017.267
IS  - British Journal of Cancer
VL  - 117
IS  - 7
SP  - 1063-1069
OP  - 400281
L1  - /bitstream/handle/11343/254874/PMC5625672.pdf?sequence=1&isAllowed=y
ER  -