TY  - JOUR
AU  - Sayed, M
AU  - Matsui, N
AU  - Hiraishi, N
AU  - Nikaido, T
AU  - Burrow, MF
AU  - Tagami, J
Y2  - 2020/12/17
Y1  - 2018/05/01
SN  - 1422-0067
UR  - http://hdl.handle.net/11343/254885
AB  - This study evaluated the effect of Glutathione (GSH) bio-molecule on the reduction of enamel and dentin discoloration after application of 38% silver diammine fluoride solution (SDF). One hundred and twenty bovine teeth specimens were used. The enamel and dentin specimens were divided into three groups: (1) SDF only (control); (2) SDF followed by application of a potassium iodide solution (KI); and (3) SDF mixed with 20% GSH. Half the specimens were exposed to light and the remainder kept in dark conditions (n = 10) Color changes were measured using a spectrophotometer at the following time intervals: before solution application (baseline) and immediately after application, then 3, 6, 24, 48, 72 h, and 7, 10 and 14 days. SEM/EDS analysis was performed on treated enamel and dentin. Statistical analysis was done using a repeated measures ANOVA test. The spectrophotometer results showed that the SDF group exhibited the greatest color changes under both light exposed and dark conditions, while SDF + GSH group was effective in decreasing the color changes in both light and dark conditions. The SDF + KI group showed an insignificant color changes over time. SEM/EDS analysis showed different patterns for the silver crystal formation in each group (SDF, SDF + GSH, and SDF + KI group). It was concluded GSH can effectively minimize color changes after application of SDF, especially on enamel and to a lesser extent on dentin.
LA  - English
PB  - MDPI
T1  - Effect of Glutathione Bio-Molecule on Tooth Discoloration Associated with Silver Diammine Fluoride
DO  - 10.3390/ijms19051322
IS  - International Journal of Molecular Sciences
VL  - 19
IS  - 5
L1  - /bitstream/handle/11343/254885/PMC5983840.pdf?sequence=1&isAllowed=y
ER  -