TY  - JOUR
AU  - Mladenova, D
AU  - Barry, G
AU  - Konen, LM
AU  - Pineda, SS
AU  - Guennewig, B
AU  - Avesson, L
AU  - Zinn, R
AU  - Schonrock, N
AU  - Bitar, M
AU  - Jonkhout, N
AU  - Crumlish, L
AU  - Kaczorowski, DC
AU  - Gong, A
AU  - Pinese, M
AU  - Franco, GR
AU  - Walkley, CR
AU  - Vissel, B
AU  - Mattick, JS
Y2  - 2020/12/17
Y1  - 2018/04/13
SN  - 1662-453X
UR  - http://hdl.handle.net/11343/254995
AB  - The amount of regulatory RNA encoded in the genome and the extent of RNA editing by the post-transcriptional deamination of adenosine to inosine (A-I) have increased with developmental complexity and may be an important factor in the cognitive evolution of animals. The newest member of the A-I editing family of ADAR proteins, the vertebrate-specific ADAR3, is highly expressed in the brain, but its functional significance is unknown. In vitro studies have suggested that ADAR3 acts as a negative regulator of A-I RNA editing but the scope and underlying mechanisms are also unknown. Meta-analysis of published data indicates that mouse Adar3 expression is highest in the hippocampus, thalamus, amygdala, and olfactory region. Consistent with this, we show that mice lacking exon 3 of Adar3 (which encodes two double stranded RNA binding domains) have increased levels of anxiety and deficits in hippocampus-dependent short- and long-term memory formation. RNA sequencing revealed a dysregulation of genes involved in synaptic function in the hippocampi of Adar3-deficient mice. We also show that ADAR3 transiently translocates from the cytoplasm to the nucleus upon KCl-mediated activation in SH-SY5Y cells. These results indicate that ADAR3 contributes to cognitive processes in mammals.
LA  - English
PB  - FRONTIERS MEDIA SA
T1  - Adar3 Is Involved in Learning and Memory in Mice
DO  - 10.3389/fnins.2018.00243
IS  - Frontiers in Neuroscience
VL  - 12
IS  - APR
L1  - /bitstream/handle/11343/254995/PMC5914295.pdf?sequence=1&isAllowed=y
ER  -