TY  - JOUR
AU  - Iles, MM
AU  - Bishop, DT
AU  - Taylor, JC
AU  - Hayward, NK
AU  - Brossard, M
AU  - Cust, AE
AU  - Dunning, AM
AU  - Lee, JE
AU  - Moses, EK
AU  - Akslen, LA
AU  - AMFS Investigators,
AU  - Andresen, PA
AU  - Avril, M-F
AU  - Azizi, E
AU  - Scarrà, GB
AU  - Brown, KM
AU  - Dębniak, T
AU  - Elder, DE
AU  - Friedman, E
AU  - Ghiorzo, P
AU  - Gillanders, EM
AU  - Goldstein, AM
AU  - Gruis, NA
AU  - Hansson, J
AU  - Harland, M
AU  - Helsing, P
AU  - Hočevar, M
AU  - Höiom, V
AU  - IBD investigators,
AU  - Ingvar, C
AU  - Kanetsky, PA
AU  - Landi, MT
AU  - Lang, J
AU  - Lathrop, GM
AU  - Lubiński, J
AU  - Mackie, RM
AU  - Martin, NG
AU  - Molven, A
AU  - Montgomery, GW
AU  - Novaković, S
AU  - Olsson, H
AU  - Puig, S
AU  - Puig-Butille, JA
AU  - QMEGA and QTWIN Investigators,
AU  - Radford-Smith, GL
AU  - Randerson-Moor, J
AU  - SDH Study Group,
AU  - van der Stoep, N
AU  - van Doorn, R
AU  - Whiteman, DC
AU  - MacGregor, S
AU  - Pooley, KA
AU  - Ward, SV
AU  - Mann, GJ
AU  - Amos, CI
AU  - Pharoah, PDP
AU  - Demenais, F
AU  - Law, MH
AU  - Newton Bishop, JA
AU  - Barrett, JH
AU  - GenoMEL Consortium,
Y2  - 2020/12/17
Y1  - 2014/10
SN  - 0027-8874
UR  - http://hdl.handle.net/11343/255081
AB  - Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10(-9), two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.
LA  - eng
PB  - Oxford University Press (OUP)
T1  - The effect on melanoma risk of genes previously associated with telomere length.
DO  - 10.1093/jnci/dju267
IS  - Journal of the National Cancer Institute
VL  - 106
IS  - 10
SP  - dju267--
L1  - /bitstream/handle/11343/255081/PMC4196080.pdf?sequence=1&isAllowed=y
ER  -