TY  - JOUR
AU  - Deliyanti, D
AU  - Talia, DM
AU  - Zhu, T
AU  - Maxwell, MJ
AU  - Agrotis, A
AU  - Jerome, JR
AU  - Hargreaves, EM
AU  - Gerondakis, S
AU  - Hibbs, ML
AU  - Mackay, F
AU  - Wilkinson-Berka, JL
Y2  - 2020/12/17
Y1  - 2017/09/29
SN  - 2041-1723
UR  - http://hdl.handle.net/11343/255133
AB  - Neovascular retinopathies are major causes of vision loss; yet treatments to prevent the condition are inadequate. The role of regulatory T cells in neovascular retinopathy is unknown. Here we show that in retinopathy regulatory T cells are transiently increased in lymphoid organs and the retina, but decline when neovascularization is established. The decline is prevented following regulatory T cells expansion with an IL-2/anti-IL-2 mAb complex or the adoptive transfer of regulatory T cells. Further, both approaches reduce vasculopathy (vaso-obliteration, neovascularization, vascular leakage) and alter the activation of Tmem119+ retinal microglia. Our in vitro studies complement these findings, showing that retinal microglia co-cultured with regulatory T cells exhibit a reduction in co-stimulatory molecules and pro-inflammatory mediators that is attenuated by CTLA-4 blockade. Collectively, we demonstrate that regulatory T cells are recruited to the retina and, when expanded in number, repair the vasculature. Manipulation of regulatory T cell numbers is a previously unrecognized, and promising avenue for therapies to prevent blinding neovascular retinopathies.The local immune responses in the eye are attenuated to preserve sight. Surprisingly, Deliyanti et al. show that regulatory T cells (Tregs) take an active role in protecting the eye from neovascularization in oxygen-induced retinopathy, and that interventions that augment the retinal Treg numbers reduce neovascular retinopathy in mice.
LA  - English
PB  - NATURE PUBLISHING GROUP
T1  - Foxp3(+) Tregs are recruited to the retina to repair pathological angiogenesis
DO  - 10.1038/s41467-017-00751-w
IS  - Nature Communications
VL  - 8
IS  - 1
L1  - /bitstream/handle/11343/255133/PMC5622066.pdf?sequence=1&isAllowed=y
ER  -