TY  - JOUR
AU  - Cole, JH
AU  - Filippetti, ML
AU  - Allin, MPG
AU  - Walshe, M
AU  - Nam, KW
AU  - Gutman, BA
AU  - Murray, RM
AU  - Rifkin, L
AU  - Thompson, PM
AU  - Nosarti, C
Y2  - 2020/12/17
Y1  - 2015
SN  - 1932-6203
UR  - http://hdl.handle.net/11343/255320
AB  - BACKGROUND: The hippocampus has been reported to be structurally and functionally altered as a sequel of very preterm birth (<33 weeks gestation), possibly due its vulnerability to hypoxic-ischemic damage in the neonatal period. We examined hippocampal volumes and subregional morphology in very preterm born individuals in mid- and late adolescence and their association with psychiatric outcome. METHODS: Structural brain magnetic resonance images were acquired at two time points (baseline and follow-up) from 65 ex-preterm adolescents (mean age = 15.5 and 19.6 years) and 36 term-born controls (mean age=15.0 and 19.0 years). Hippocampal volumes and subregional morphometric differences were measured from manual tracings and with three-dimensional shape analysis. Psychiatric outcome was assessed with the Rutter Parents' Scale at baseline, the General Health Questionnaire at follow-up and the Peters Delusional Inventory at both time points. RESULTS: In contrast to previous studies we did not find significant difference in the cross-sectional or longitudinal hippocampal volumes between individuals born preterm and controls, despite preterm individual having significantly smaller whole brain volumes. Shape analysis at baseline revealed subregional deformations in 28% of total bilateral hippocampal surface, reflecting atrophy, in ex-preterm individuals compared to controls, and in 22% at follow-up. In ex-preterm individuals, longitudinal changes in hippocampal shape accounted for 11% of the total surface, while in controls they reached 20%. In the whole sample (both groups) larger right hippocampal volume and bilateral anterior surface deformations at baseline were associated with delusional ideation scores at follow-up. CONCLUSIONS: This study suggests a dynamic association between cross-sectional hippocampal volumes, longitudinal changes and surface deformations and psychosis proneness.
LA  - eng
PB  - Public Library of Science (PLoS)
T1  - Subregional Hippocampal Morphology and Psychiatric Outcome in Adolescents Who Were Born Very Preterm and at Term.
DO  - 10.1371/journal.pone.0130094
IS  - PLoS One
VL  - 10
IS  - 6
SP  - e0130094-
L1  - /bitstream/handle/11343/255320/PMC4474892.pdf?sequence=1&isAllowed=y
ER  -