TY  - JOUR
AU  - Phu, J
AU  - Khuu, SK
AU  - Nivison-Smith, L
AU  - Zangerl, B
AU  - Choi, AYJ
AU  - Jones, BW
AU  - Pfeiffer, RL
AU  - Marc, RE
AU  - Kalloniatis, M
Y2  - 2020/12/17
Y1  - 2017/09/01
SN  - 0146-0404
UR  - http://hdl.handle.net/11343/255402
AB  - Purpose: To determine the locus of test locations that exhibit statistically similar age-related decline in sensitivity to light increments and age-corrected contrast sensitivity isocontours (CSIs) across the central visual field (VF). We compared these CSIs with test point clusters used by the Glaucoma Hemifield Test (GHT). Methods: Sixty healthy observers underwent testing on the Humphrey Field Analyzer 30-2 test grid using Goldmann (G) stimulus sizes I-V. Age-correction factors for GI-V were determined using linear regression analysis. Pattern recognition analysis was used to cluster test locations across the VF exhibiting equal age-related sensitivity decline (age-related CSIs), and points of equal age-corrected sensitivity (age-corrected CSIs) for GI-V. Results: There was a small but significant test size-dependent sensitivity decline with age, with smaller stimuli declining more rapidly. Age-related decline in sensitivity was more rapid in the periphery. A greater number of unique age-related CSIs was revealed when using smaller stimuli, particularly in the mid-periphery. Cluster analysis of age-corrected sensitivity thresholds revealed unique CSIs for GI-V, with smaller stimuli having a greater number of unique clusters. Zones examined by the GHT consisted of test locations that did not necessarily belong to the same CSI, particularly in the periphery. Conclusions: Cluster analysis reveals statistically significant groups of test locations within the 30-2 test grid exhibiting the same age-related decline. CSIs facilitate pooling of sensitivities to reduce the variability of individual test locations. These CSIs could guide future structure-function and alternate hemifield asymmetry analyses by comparing matched areas of similar sensitivity signatures.
LA  - English
PB  - ASSOC RESEARCH VISION OPHTHALMOLOGY INC
T1  - Pattern Recognition Analysis Reveals Unique Contrast Sensitivity Isocontours Using Static Perimetry Thresholds Across the Visual Field
DO  - 10.1167/iovs.17-22371
IS  - Investigative Ophthalmology and Visual Science
VL  - 58
IS  - 11
SP  - 4863-4876
L1  - /bitstream/handle/11343/255402/PMC5624776.pdf?sequence=1&isAllowed=y
ER  -