TY  - JOUR
AU  - Shen, J
AU  - Liao, Y
AU  - Hopper, JL
AU  - Goldberg, M
AU  - Santella, RM
AU  - Terry, MB
Y2  - 2020/12/18
Y1  - 2017/04/01
SN  - 0007-0920
UR  - http://hdl.handle.net/11343/255692
AB  - BACKGROUND: Most studies of environmental risk factors and breast cancer are conducted using average risk cohorts. METHODS: We examined the association between polycyclic aromatic hydrocarbon (PAH)-albumin adducts in bloods from baseline and breast cancer risk in a prospective nested case-control study (New York site of the BCFR, 80 cases and 156 controls). We estimated the 10-year absolute breast cancer risk by a risk model that uses pedigree information (BOADICEA) and evaluated whether the increased risk from PAH differed by absolute risk. RESULTS: Women with detectable levels of PAH had a twofold association with breast cancer risk (odds ratio (OR)=2.04; 95% CI=1.06-3.93) relative to women with non-detectable levels. The association increased with higher levels of PAH (⩾median) and by a higher level of absolute breast cancer risk (10-year risk ⩾3.4%: OR=4.09, 95% CI=1.38-12.13). CONCLUSIONS: These results support that family-based cohorts can be an efficient way to examine gene-environment interactions.
LA  - English
PB  - NATURE PUBLISHING GROUP
T1  - Dependence of cancer risk from environmental exposures on underlying genetic susceptibility: an illustration with polycyclic aromatic hydrocarbons and breast cancer
DO  - 10.1038/bjc.2017.81
IS  - British Journal of Cancer
VL  - 116
IS  - 9
SP  - 1229-1233
L1  - /bitstream/handle/11343/255692/PMC5418454.pdf?sequence=1&isAllowed=y
ER  -