TY  - JOUR
AU  - Binger, KJ
AU  - Corte-Real, BF
AU  - Kleinewietfeld, M
Y2  - 2020/12/18
Y1  - 2017/03/21
SN  - 1664-3224
UR  - http://hdl.handle.net/11343/255700
AB  - Interleukin-17-producing T helper (Th17) cells are critical for the host defense of bacterial and fungal pathogens and also play a major role in driving pathogenic autoimmune responses. Recent studies have indicated that the generation of Th17 cells from naïve CD4+ T cells is coupled with massive cellular metabolic adaptations, necessary to cope with different energy and metabolite requirements associated with switching from a resting to proliferative state. Furthermore, Th17 cells have to secure these metabolic adaptations when facing nutrient-limiting environments, such as at the sites of inflammation. Accumulating data indicates that this metabolic reprogramming is significantly linked to the differentiation of T helper cells and, particularly, that the metabolic changes of Th17 cells and anti-inflammatory Forkhead box P3+ regulatory T cells are tightly and reciprocally regulated. Thus, a better understanding of these processes could offer potential new targets for therapeutic interventions for autoimmune diseases. In this mini-review, we will highlight some of the recent advances and discoveries in the field, with a particular focus on metabolic demands of Th17 cells and their implications for autoimmunity.
LA  - English
PB  - FRONTIERS MEDIA SA
T1  - Immunometabolic Regulation of Interleukin-17-Producing T Helper Cells: Uncoupling New Targets for Autoimmunity
DO  - 10.3389/fimmu.2017.00311
IS  - Frontiers in Immunology
VL  - 8
IS  - MAR
OP  - 1037633
L1  - /bitstream/handle/11343/255700/PMC5359241.pdf?sequence=1&isAllowed=y
ER  -