TY  - JOUR
AU  - Moore, JWJ
AU  - Moyo, D
AU  - Beattie, L
AU  - Andrews, PS
AU  - Timmis, J
AU  - Kaye, PM
Y2  - 2020/12/18
Y1  - 2013/01/01
SN  - 1664-3224
UR  - http://hdl.handle.net/11343/256065
AB  - In human and canine visceral leishmaniasis and in various experimental models of this disease, host resistance is strongly linked to efficient granuloma development. However, it is unknown exactly how the granuloma microenvironment executes an effective antileishmanial response. Recent studies, including using advanced imaging techniques, have improved our understanding of granuloma biology at the cellular level, highlighting heterogeneity in granuloma development and function, and hinting at complex cellular, temporal, and spatial dynamics. In this mini-review, we discuss the factors involved in the formation and function of Leishmania donovani-induced hepatic granulomas, as well as their importance in protecting against inflammation-associated tissue damage and the generation of immunity to rechallenge. Finally, we discuss the role that computational, agent-based models may play in answering outstanding questions within the field.
LA  - English
PB  - FRONTIERS MEDIA SA
T1  - Functional complexity of the Leishmania granuloma and the potential of in silico modeling
DO  - 10.3389/fimmu.2013.00035
IS  - Frontiers in Immunology
VL  - 4
IS  - FRB
L1  - /bitstream/handle/11343/256065/PMC3573688.pdf?sequence=1&isAllowed=y
ER  -