TY  - JOUR
AU  - Brodie, EJ
AU  - Infantino, S
AU  - Low, MSY
AU  - Tarlinton, DM
Y2  - 2020/12/18
Y1  - 2018/03/01
SN  - 1664-3224
UR  - http://hdl.handle.net/11343/256081
AB  - Systemic lupus erythematosus (SLE) is a progressive autoimmune disease characterized by increased sensitivity to self-antigens, auto-antibody production, and systemic inflammation. B cells have been implicated in disease progression and as such represent an attractive therapeutic target. Lyn is a Src family tyrosine kinase that plays a major role in regulating signaling pathways within B cells as well as other hematopoietic cells. Its role in initiating negative signaling cascades is especially critical as exemplified by Lyn-/- mice developing an SLE-like disease with plasma cell hyperplasia, underscoring the importance of tightly regulating signaling within B cells. This review highlights recent advances in our understanding of the function of the Src family tyrosine kinase Lyn in B lymphocytes and its contribution to positive and negative signaling pathways that are dysregulated in autoimmunity.
LA  - English
PB  - FRONTIERS MEDIA SA
T1  - Lyn, Lupus, and (B) Lymphocytes, a Lesson on the Critical Balance of Kinase Signaling in immunity
DO  - 10.3389/fimmu.2018.00401
IS  - Frontiers in Immunology
VL  - 9
IS  - MAR
L1  - /bitstream/handle/11343/256081/PMC5837976.pdf?sequence=1&isAllowed=y
ER  -