TY  - JOUR
AU  - Pavuluri, S
AU  - Sharp, JA
AU  - Lefevre, C
AU  - Nicholas, KR
Y2  - 2020/12/18
Y1  - 2018/01/27
SN  - 1513-7368
UR  - http://hdl.handle.net/11343/256150
AB  - Extracellular matrix (ECM) plays an important role in the normal physiology of tissues and progression to disease.
Earlier studies and our external microarray data analysis indicated that mammary matrix from involuting tissue showed
upregulation of genes involved in ECM remodeling. The present study examines the fate of mammary and oral cancer
cells grown in the ECM from lactating mammary gland. Our findings show that non-tumorigenic cells, MCF10A and
DOK cells did not proliferate but the tumorigenic and metastatic cells, SCC25 and MDA-MB-231, underwent apoptosis
when grown on mammary ECM isolated from lactating mice. In addition, the cytokinesis marker, CEP55, was repressed
in the oral and breast cancer cells. In contrast, these cells proliferated normally on mammary ECM isolated from mice
undergoing involution. External microarray data analysis of mammary tissue further revealed over expression (~16 fold)
of QSOX1 gene, which promotes cellular quiescence, in lactating mammary gland. A recent study has indicated that
QSOX1 overexpression in breast cancer cells led to reduced proliferation and tumorigenic properties. This extracellular
protein in mammary ECM may be responsible for reduced cellular proliferation. The present study has shown that ECM
from lactating mammary gland can regulate signals to oral and breast cancer cells to halt cell division. This preliminary
observation provided insights into the potential role of ECM factors present in lactating mammary gland as therapeutic
targets to control cancer cell division. This preliminary study is an attempt to understand not only the requirement of
ECM remodeling factors essential for the growth and survival of cancer cells but also the factors present in the lactation
matrix that simultaneously halts cell division and selectively inhibits the growth of cancer cells.
LA  - eng
T1  - The Effect of Mammary Extracellular Matrix in Controlling Oral and Mammary Cancer Cells
DO  - 10.22034/APJCP.2018.19.1.57
IS  - Asian Pacific Journal of Cancer Prevention
VL  - 19
IS  - 1
SP  - 57-63
L1  - /bitstream/handle/11343/256150/PMC5844637.pdf?sequence=1&isAllowed=y
ER  -