TY  - JOUR
AU  - Shalapour, S
AU  - Deiser, K
AU  - Kühl, AA
AU  - Glauben, R
AU  - Krug, SM
AU  - Fischer, A
AU  - Sercan, O
AU  - Chappaz, S
AU  - Bereswill, S
AU  - Heimesaat, MM
AU  - Loddenkemper, C
AU  - Fromm, M
AU  - Finke, D
AU  - Hämmerling, GJ
AU  - Arnold, B
AU  - Siegmund, B
AU  - Schüler, T
Y2  - 2020/12/18
Y1  - 2012
SN  - 1932-6203
UR  - http://hdl.handle.net/11343/256228
AB  - Interleukin-7 (IL-7) is a major survival factor for mature T cells. Therefore, the degree of IL-7 availability determines the size of the peripheral T cell pool and regulates T cell homeostasis. Here we provide evidence that IL-7 also regulates the homeostasis of intestinal epithelial cells (IEC), colon function and the composition of the commensal microflora. In the colon of T cell-deficient, lymphopenic mice, IL-7-producing IEC accumulate. IEC hyperplasia can be blocked by IL-7-consuming T cells or the inactivation of the IL-7/IL-7R signaling pathway. However, the blockade of the IL-7/IL-7R signaling pathway renders T cell-deficient mice more sensitive to chemically-induced IEC damage and subsequent colitis. In summary, our data demonstrate that IL-7 promotes IEC hyperplasia under lymphopenic conditions. Under non-lymphopenic conditions, however, T cells consume IL-7 thereby limiting IEC expansion and survival. Hence, the degree of IL-7 availability regulates both, T cell and IEC homeostasis.
LA  - eng
PB  - Public Library of Science (PLoS)
T1  - Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis.
DO  - 10.1371/journal.pone.0031939
IS  - PLoS One
VL  - 7
IS  - 2
SP  - e31939-
L1  - /bitstream/handle/11343/256228/PMC3288069.pdf?sequence=1&isAllowed=y
ER  -