TY  - JOUR
AU  - Almeida, FF
AU  - Tenno, M
AU  - Brzostek, J
AU  - Li, JL
AU  - Allies, G
AU  - Hoeffel, G
AU  - See, P
AU  - Ng, LG
AU  - Fehling, HJ
AU  - Gascoigne, NRJ
AU  - Taniuchi, I
AU  - Ginhoux, F
Y2  - 2020/12/18
Y1  - 2015/07/30
SN  - 2045-2322
UR  - http://hdl.handle.net/11343/256264
AB  - T cell progenitors are known to arise from the foetal liver in embryos and the bone marrow in adults; however different studies have shown that a pool of T cell progenitors may also exist in the periphery. Here, we identified a lymphoid population resembling peripheral T cell progenitors which transiently seed the epidermis during late embryogenesis in both wild-type and T cell-deficient mice. We named these cells ELCs (Epidermal Lymphoid Cells). ELCs expressed Thy1 and CD2, but lacked CD3 and TCRαβ/γδ at their surface, reminiscent of the phenotype of extra- or intra- thymic T cell progenitors. Similarly to Dendritic Epidermal T Cells (DETCs), ELCs were radioresistant and capable of self-renewal. However, despite their progenitor-like phenotype and expression of T cell lineage markers within the population, ELCs did not differentiate into conventional T cells or DETCs in in vitro, ex vivo or in vivo differentiation assays. Finally, we show that ELC expressed NK markers and secreted IFN-γ upon stimulation. Therefore we report the discovery of a unique population of lymphoid cells within the murine epidermis that appears related to NK cells with as-yet-unidentified functions.
LA  - eng
PB  - Springer Science and Business Media LLC
T1  - Identification of a novel lymphoid population in the murine epidermis.
DO  - 10.1038/srep12554
IS  - Scientific Reports
VL  - 5
IS  - 1
SP  - 12554-
L1  - /bitstream/handle/11343/256264/PMC4519784.pdf?sequence=1&isAllowed=y
ER  -