TY  - JOUR
AU  - Fan, J
AU  - Bernardi, S
AU  - Van Dam, NT
AU  - Anagnostou, E
AU  - Gu, X
AU  - Martin, L
AU  - Park, Y
AU  - Liu, X
AU  - Kolevzon, A
AU  - Soorya, L
AU  - Grodberg, D
AU  - Hollander, E
AU  - Hof, PR
Y2  - 2020/12/21
Y1  - 2012/09/01
SN  - 2162-3279
UR  - http://hdl.handle.net/11343/256385
AB  - Attentional dysfunction is among the most consistent observations of autism spectrum disorders (ASD). However, the neural nature of this deficit in ASD is still unclear. In this study, we aimed to identify the neurobehavioral correlates of attentional dysfunction in ASD. We used the Attention Network Test-Revised and functional magnetic resonance imaging to examine alerting, orienting, and executive control functions, as well as the neural substrates underlying these attentional functions in unmedicated, high-functioning adults with ASD (n = 12) and matched healthy controls (HC, n = 12). Compared with HC, individuals with ASD showed increased error rates in alerting and executive control, accompanied by lower activity in the mid-frontal gyrus and the caudate nucleus for alerting, and by the absence of significant functional activation in the anterior cingulate cortex (ACC) for executive control. In addition, greater behavioral deficiency in executive control in ASD was correlated with less functional activation of the ACC. These findings of behavioral and neural abnormalities in alerting and executive control of attention in ASD may suggest core attentional deficits, which require further investigation.
LA  - English
PB  - JOHN WILEY & SONS INC
T1  - Functional deficits of the attentional networks in autism
DO  - 10.1002/brb3.90
IS  - Brain and Behavior
VL  - 2
IS  - 5
SP  - 647-660
L1  - /bitstream/handle/11343/256385/PMC3489817.pdf?sequence=1&isAllowed=y
ER  -