TY  - JOUR
AU  - Bulj, Z
AU  - Duchi, S
AU  - Bevilacqua, A
AU  - Gherardi, A
AU  - Dozza, B
AU  - Piccinini, F
AU  - Mariani, GA
AU  - Lucarelli, E
AU  - Giannini, S
AU  - Donati, D
AU  - Marmiroli, S
Y2  - 2020/12/21
Y1  - 2013/01/01
SN  - 1019-6439
UR  - http://hdl.handle.net/11343/256536
AB  - This study was designed to investigate the migratory behavior of adult human             mesenchymal stem cells (MSC) and the underlying mechanism. Cell migration was             assessed by transwell, wound healing and time-lapse in vivo motility assays. Pharmacological             inhibitors were used to determine the potential mechanism responsible for cell             migration and invasion. The tests that were implemented revealed that MSC were             fairly migratory. Protein kinase B (AKT) was strongly activated at the basal level.             Through our analyses we demonstrated that pharmacological inactivation of AKT2             but not AKT1 significantly decreased cell migration and invasion. Although preliminary,             collectively our results indicate that AKT2 activation plays a critical role in             enabling MSC migration.
LA  - English
PB  - SPANDIDOS PUBL LTD
T1  - Protein kinase B/AKT isoform 2 drives migration of human mesenchymal stem cells
DO  - 10.3892/ijo.2012.1700
IS  - International Journal of Oncology
VL  - 42
IS  - 1
SP  - 118-126
L1  - /bitstream/handle/11343/256536/PMC3583637.pdf?sequence=1&isAllowed=y
ER  -