TY  - JOUR
AU  - Wiede, F
AU  - Dudakov, JA
AU  - Lu, K-H
AU  - Dodd, GT
AU  - Butt, T
AU  - Godfrey, DI
AU  - Strasser, A
AU  - Boyd, RL
AU  - Tiganis, T
Y2  - 2020/12/21
Y1  - 2017/09/01
SN  - 0022-1007
UR  - http://hdl.handle.net/11343/256744
AB  - In the thymus, hematopoietic progenitors commit to the T cell lineage and undergo sequential differentiation to generate diverse T cell subsets, including major histocompatibility complex (MHC)-restricted αβ T cell receptor (TCR) T cells and non-MHC-restricted γδ TCR T cells. The factors controlling precursor commitment and their subsequent maturation and specification into αβ TCR versus γδ TCR T cells remain unclear. Here, we show that the tyrosine phosphatase PTPN2 attenuates STAT5 (signal transducer and activator of transcription 5) signaling to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 signaling to regulate αβ TCR versus γδ TCR T cell development. Our findings identify PTPN2 as an important regulator of critical checkpoints that dictate the commitment of multipotent precursors to the T cell lineage and their subsequent maturation into αβ TCR or γδ TCR T cells.
LA  - English
PB  - ROCKEFELLER UNIV PRESS
T1  - PTPN2 regulates T cell lineage commitment and alpha beta versus gamma delta specification
DO  - 10.1084/jem.20161903
IS  - Journal of Experimental Medicine
VL  - 214
IS  - 9
SP  - 2733-2758
L1  - /bitstream/handle/11343/256744/PMC5584121.pdf?sequence=1&isAllowed=y
ER  -