TY - JOUR AU - Wiede, F AU - Dudakov, JA AU - Lu, K-H AU - Dodd, GT AU - Butt, T AU - Godfrey, DI AU - Strasser, A AU - Boyd, RL AU - Tiganis, T Y2 - 2020/12/21 Y1 - 2017/09/01 SN - 0022-1007 UR - http://hdl.handle.net/11343/256744 AB - In the thymus, hematopoietic progenitors commit to the T cell lineage and undergo sequential differentiation to generate diverse T cell subsets, including major histocompatibility complex (MHC)-restricted αβ T cell receptor (TCR) T cells and non-MHC-restricted γδ TCR T cells. The factors controlling precursor commitment and their subsequent maturation and specification into αβ TCR versus γδ TCR T cells remain unclear. Here, we show that the tyrosine phosphatase PTPN2 attenuates STAT5 (signal transducer and activator of transcription 5) signaling to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 signaling to regulate αβ TCR versus γδ TCR T cell development. Our findings identify PTPN2 as an important regulator of critical checkpoints that dictate the commitment of multipotent precursors to the T cell lineage and their subsequent maturation into αβ TCR or γδ TCR T cells. LA - English PB - ROCKEFELLER UNIV PRESS T1 - PTPN2 regulates T cell lineage commitment and alpha beta versus gamma delta specification DO - 10.1084/jem.20161903 IS - Journal of Experimental Medicine VL - 214 IS - 9 SP - 2733-2758 L1 - /bitstream/handle/11343/256744/PMC5584121.pdf?sequence=1&isAllowed=y ER -