TY  - JOUR
AU  - Ritchie, ME
AU  - Carvalho, BS
AU  - Hetrick, KN
AU  - Tavare, S
AU  - Irizarry, RA
Y2  - 2020/12/21
Y1  - 2009/10/01
SN  - 1367-4803
UR  - http://hdl.handle.net/11343/256766
AB  - UNLABELLED: Illumina produces a number of microarray-based technologies for human genotyping. An Infinium BeadChip is a two-color platform that types between 10(5) and 10(6) single nucleotide polymorphisms (SNPs) per sample. Despite being widely used, there is a shortage of open source software to process the raw intensities from this platform into genotype calls. To this end, we have developed the R/Bioconductor package crlmm for analyzing BeadChip data. After careful preprocessing, our software applies the CRLMM algorithm to produce genotype calls, confidence scores and other quality metrics at both the SNP and sample levels. We provide access to the raw summary-level intensity data, allowing users to develop their own methods for genotype calling or copy number analysis if they wish. AVAILABILITY AND IMPLEMENTATION: The crlmm Bioconductor package is available from http://www.bioconductor.org. Data packages and documentation are available from http://rafalab.jhsph.edu/software.html.
LA  - English
PB  - OXFORD UNIV PRESS
T1  - R/Bioconductor software for Illumina's Infinium whole-genome genotyping BeadChips
DO  - 10.1093/bioinformatics/btp470
IS  - Bioinformatics
VL  - 25
IS  - 19
SP  - 2621-2623
L1  - /bitstream/handle/11343/256766/PMC2752620.pdf?sequence=1&isAllowed=y
ER  -