TY  - JOUR
AU  - Dziegelewska, M
AU  - Holtze, S
AU  - Vole, C
AU  - Wachter, U
AU  - Menzel, U
AU  - Morhart, M
AU  - Groth, M
AU  - Szafranski, K
AU  - Sahm, A
AU  - Sponholz, C
AU  - Dammannc, P
AU  - Huse, K
AU  - Hildebrandt, T
AU  - Platzer, M
Y2  - 2020/12/21
Y1  - 2016/08/01
SN  - 2213-2317
UR  - http://hdl.handle.net/11343/256968
AB  - Hydrogen sulfide (H2S) is a gaseous signalling molecule involved in many physiological and pathological processes. There is increasing evidence that H2S is implicated in aging and lifespan control in the diet-induced longevity models. However, blood sulfide concentration of naturally long-lived species is not known. Here we measured blood sulfide in the long-lived naked mole-rat and five other mammalian species considerably differing in lifespan and found a negative correlation between blood sulfide and maximum longevity residual. In addition, we show that the naked mole-rat cystathionine β-synthase (CBS), an enzyme whose activity in the liver significantly contributes to systemic sulfide levels, has lower activity in the liver and is activated to a higher degree by S-adenosylmethionine compared to other species. These results add complexity to the understanding of the role of H2S in aging and call for detailed research on naked mole-rat transsulfuration.
LA  - English
PB  - ELSEVIER SCIENCE BV
T1  - Low sulfide levels and a high degree of cystathionine p-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat
DO  - 10.1016/j.redox.2016.01.008
IS  - Redox Biology
VL  - 8
SP  - 192-198
L1  - /bitstream/handle/11343/256968/PMC4732021.pdf?sequence=1&isAllowed=y
ER  -