TY - JOUR AU - Dziegelewska, M AU - Holtze, S AU - Vole, C AU - Wachter, U AU - Menzel, U AU - Morhart, M AU - Groth, M AU - Szafranski, K AU - Sahm, A AU - Sponholz, C AU - Dammannc, P AU - Huse, K AU - Hildebrandt, T AU - Platzer, M Y2 - 2020/12/21 Y1 - 2016/08/01 SN - 2213-2317 UR - http://hdl.handle.net/11343/256968 AB - Hydrogen sulfide (H2S) is a gaseous signalling molecule involved in many physiological and pathological processes. There is increasing evidence that H2S is implicated in aging and lifespan control in the diet-induced longevity models. However, blood sulfide concentration of naturally long-lived species is not known. Here we measured blood sulfide in the long-lived naked mole-rat and five other mammalian species considerably differing in lifespan and found a negative correlation between blood sulfide and maximum longevity residual. In addition, we show that the naked mole-rat cystathionine β-synthase (CBS), an enzyme whose activity in the liver significantly contributes to systemic sulfide levels, has lower activity in the liver and is activated to a higher degree by S-adenosylmethionine compared to other species. These results add complexity to the understanding of the role of H2S in aging and call for detailed research on naked mole-rat transsulfuration. LA - English PB - ELSEVIER SCIENCE BV T1 - Low sulfide levels and a high degree of cystathionine p-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat DO - 10.1016/j.redox.2016.01.008 IS - Redox Biology VL - 8 SP - 192-198 L1 - /bitstream/handle/11343/256968/PMC4732021.pdf?sequence=1&isAllowed=y ER -