TY  - JOUR
AU  - Hoa, LNM
AU  - Bryant, JE
AU  - Choisy, M
AU  - Nguyet, LA
AU  - Bao, NT
AU  - Trang, NH
AU  - Chuc, NTK
AU  - Toan, TK
AU  - Saito, T
AU  - Takemae, N
AU  - Horby, P
AU  - Wertheim, H
AU  - Fox, A
Y2  - 2020/12/21
Y1  - 2015/10
SN  - 0950-2688
UR  - http://hdl.handle.net/11343/257346
AB  - A reassortant swine-origin A(H3N2) virus (A/swine/BinhDuong/03-9/2010) was detected through swine surveillance programmes in southern Vietnam in 2010. This virus contains haemagglutinin and neuraminidase genes from a human A(H3N2) virus circulating around 2004-2006, and the internal genes from triple-reassortant swine influenza A viruses (IAVs). To assess population susceptibility to this virus we measured haemagglutination inhibiting (HI) titres to A/swine/BinhDuong/03-9/2010 and to seasonal A/Perth/16/2009 for 947 sera collected from urban and rural Vietnamese people during 2011-2012. Seroprevalence (HI ⩾ 40) was high and similar for both viruses, with 62·6% [95% confidence interval (CI) 59·4-65·7] against A/Perth/16/2009 and 54·6% (95% CI 51·4-57·8%) against A/swine/BinhDuong/03-9/2010, and no significant differences between urban and rural participants. Children aged <5 years lacked antibodies to the swine origin H3 virus despite high seroprevalence for A/Perth/16/2009. These results reveal vulnerability to infection to this contemporary swine IAV in children aged <5 years; however, cross-reactive immunity in adults would likely limit epidemic emergence potential.
LA  - eng
PB  - Cambridge University Press (CUP)
T1  - Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011-2012.
DO  - 10.1017/S0950268815000187
IS  - Epidemiology and Infection
VL  - 143
IS  - 14
SP  - 2959-2964
L1  - /bitstream/handle/11343/257346/PMC4595856.pdf?sequence=1&isAllowed=y
ER  -