TY - JOUR AU - de Jonge, MD AU - Ryan, CG AU - Jacobsen, CJ Y2 - 2020/12/21 Y1 - 2014/09/01 SN - 0909-0495 UR - http://hdl.handle.net/11343/257426 AB - X-ray nanoprobes require coherent illumination to achieve optic-limited resolution, and so will benefit directly from diffraction-limited storage rings. Here, the example of high-resolution X-ray fluorescence tomography is focused on as one of the most voracious demanders of coherent photons, since the detected signal is only a small fraction of the incident flux. Alternative schemes are considered for beam delivery, sample scanning and detectors. One must consider as well the steps before and after the X-ray experiment: sample preparation and examination conditions, and analysis complexity due to minimum dose requirements and self-absorption. By understanding the requirements and opportunities for nanoscale fluorescence tomography, one gains insight into the R&D challenges in optics and instrumentation needed to fully exploit the source advances that diffraction-limited storage rings offer. LA - English PB - INT UNION CRYSTALLOGRAPHY T1 - X-ray nanoprobes and diffraction-limited storage rings: opportunities and challenges of fluorescence tomography of biological specimens DO - 10.1107/S160057751401621X IS - Journal of Synchrotron Radiation VL - 21 IS - Pt 5 SP - 1031-1047 L1 - /bitstream/handle/11343/257426/PMC4151681.pdf?sequence=1&isAllowed=y ER -