TY  - JOUR
AU  - de Jonge, MD
AU  - Ryan, CG
AU  - Jacobsen, CJ
Y2  - 2020/12/21
Y1  - 2014/09/01
SN  - 0909-0495
UR  - http://hdl.handle.net/11343/257426
AB  - X-ray nanoprobes require coherent illumination to achieve optic-limited resolution, and so will benefit directly from diffraction-limited storage rings. Here, the example of high-resolution X-ray fluorescence tomography is focused on as one of the most voracious demanders of coherent photons, since the detected signal is only a small fraction of the incident flux. Alternative schemes are considered for beam delivery, sample scanning and detectors. One must consider as well the steps before and after the X-ray experiment: sample preparation and examination conditions, and analysis complexity due to minimum dose requirements and self-absorption. By understanding the requirements and opportunities for nanoscale fluorescence tomography, one gains insight into the R&D challenges in optics and instrumentation needed to fully exploit the source advances that diffraction-limited storage rings offer.
LA  - English
PB  - INT UNION CRYSTALLOGRAPHY
T1  - X-ray nanoprobes and diffraction-limited storage rings: opportunities and challenges of fluorescence tomography of biological specimens
DO  - 10.1107/S160057751401621X
IS  - Journal of Synchrotron Radiation
VL  - 21
IS  - Pt 5
SP  - 1031-1047
L1  - /bitstream/handle/11343/257426/PMC4151681.pdf?sequence=1&isAllowed=y
ER  -