TY  - JOUR
AU  - Chen, Y
AU  - Zhang, J
AU  - Morgan, IG
AU  - He, M
Y2  - 2020/12/21
Y1  - 2016/12/28
SN  - 1932-6203
UR  - http://hdl.handle.net/11343/257548
AB  - PURPOSE: To construct reference centile curves of refraction based on population-based data as an age-specific severity scale to evaluate their efficacy as a tool for identifying children at risk of developing high myopia in a longitudinal study. METHODS: Data of 4218 children aged 5-15 years from the Guangzhou Refractive Error Study in Children (RESC) study, and 354 first-born twins from the Guangzhou Twin Eye Study (GTES) with annual visit were included in the analysis. Reference centile curves for refraction were constructed using a quantile regression model based on the cycloplegic refraction data from the RESC. The risk of developing high myopia (spherical equivalent ≤ -6 diopters [D]) was evaluated as a diagnostic test using the twin follow-up data. RESULTS: The centile curves suggested that the 3rd, 5th, and 10th percentile decreased from -0.25 D, 0.00 D and 0.25 D in 5 year-olds to -6.00 D, -5.65D and -4.63 D in 15 year-olds in the population-based data from RESC. In the GTES cohort, the 5th centile showed the most effective diagnostic value with a sensitivity of 92.9%, a specificity of 97.9% and a positive predictive value (PPV) of 65.0% in predicting high myopia onset (≤-6.00D) before the age of 15 years. The PPV was highest (87.5%) in 3rd centile but with only 50.0% sensitivity. The Mathew's correlation coefficient of 5th centile in predicting myopia of -6.0D/-5.0D/-4.0D by age of 15 was 0.77/0.51/0.30 respectively. CONCLUSIONS: Reference centile curves provide an age-specific estimation on a severity scale of refractive error in school-aged children. Children located under lower percentiles at young age were more likely to have high myopia at 15 years or probably in adulthood.
LA  - English
PB  - PUBLIC LIBRARY SCIENCE
T1  - Identifying Children at Risk of High Myopia Using Population Centile Curves of Refraction
DO  - 10.1371/journal.pone.0167642
IS  - PLoS One
VL  - 11
IS  - 12
L1  - /bitstream/handle/11343/257548/PMC5193395.pdf?sequence=1&isAllowed=y
ER  -