TY  - JOUR
AU  - Bernatsky, S
AU  - Garcia, HAV
AU  - Spinelli, JJ
AU  - Gaffney, P
AU  - Smedby, KE
AU  - Ramsey-Goldman, R
AU  - Wang, SS
AU  - Adami, H-O
AU  - Albanes, D
AU  - Angelucci, E
AU  - Ansell, SM
AU  - Asmann, YW
AU  - Becker, N
AU  - Benavente, Y
AU  - Berndt, SI
AU  - Bertrand, KA
AU  - Birmann, BM
AU  - Boeing, H
AU  - Boffetta, P
AU  - Bracci, PM
AU  - Brennan, P
AU  - Brooks-Wilson, AR
AU  - Cerhan, JR
AU  - Chanock, SJ
AU  - Clavel, J
AU  - Conde, L
AU  - Cotenbader, KH
AU  - Cox, DG
AU  - Cozen, W
AU  - Crouch, S
AU  - De Roos, AJ
AU  - de Sanjose, S
AU  - Di Lollo, S
AU  - Diver, WR
AU  - Dogan, A
AU  - Foretova, L
AU  - Ghesquieres, H
AU  - Giles, GG
AU  - Glimelius, B
AU  - Habermann, TM
AU  - Haioun, C
AU  - Hartge, P
AU  - Hjalgrim, H
AU  - Holford, TR
AU  - Holly, EA
AU  - Jackson, RD
AU  - Kaaks, R
AU  - Kane, E
AU  - Kelly, RS
AU  - Klein, RJ
AU  - Kraft, P
AU  - Kricker, A
AU  - Lan, Q
AU  - Lawrence, C
AU  - Liebow, M
AU  - Lightfoot, T
AU  - Link, BK
AU  - Maynadie, M
AU  - Mckay, J
AU  - Melbye, M
AU  - Molina, TJ
AU  - Monnereau, A
AU  - Morton, LM
AU  - Nieters, A
AU  - North, KE
AU  - Novak, AJ
AU  - Offit, K
AU  - Purdue, MP
AU  - Rais, M
AU  - Riby, J
AU  - Roman, E
AU  - Rothman, N
AU  - Salles, G
AU  - Severi, G
AU  - Severson, RK
AU  - Skibola, CF
AU  - Slager, SL
AU  - Smith, A
AU  - Smith, MT
AU  - Southey, MC
AU  - Staines, A
AU  - Teras, LR
AU  - Thompson, CA
AU  - Tilly, H
AU  - Tinker, LF
AU  - Tjonneland, A
AU  - Turner, J
AU  - Vajdic, CM
AU  - Vermeulen, RCH
AU  - Vijai, J
AU  - Vineis, P
AU  - Virtamo, J
AU  - Wang, Z
AU  - Weinstein, S
AU  - Witzig, TE
AU  - Zelenetz, A
AU  - Zeleniuch-Jacquotte, A
AU  - Zhang, Y
AU  - Zheng, T
AU  - Zucca, M
AU  - Clarke, AE
Y2  - 2020/12/21
Y1  - 2017/01/01
SN  - 2053-8790
UR  - http://hdl.handle.net/11343/257613
AB  - Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.
LA  - English
PB  - BMJ PUBLISHING GROUP
T1  - Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma
DO  - 10.1136/lupus-2016-000187
IS  - Lupus Science & Medicine
VL  - 4
IS  - 1
L1  - /bitstream/handle/11343/257613/PMC5715504.pdf?sequence=1&isAllowed=y
ER  -