TY  - JOUR
AU  - Jelley, L
AU  - Levy, A
AU  - Deng, Y-M
AU  - Spirason, N
AU  - Lang, J
AU  - Buettner, I
AU  - Druce, J
AU  - Blyth, C
AU  - Effler, P
AU  - Smith, D
AU  - Barr, IG
Y2  - 2020/12/22
Y1  - 2016/11/01
SN  - 1750-2640
UR  - http://hdl.handle.net/11343/257904
AB  - BACKGROUND: Influenza C is usually considered a minor cause of respiratory illness in humans with many infections being asymptomatic or clinically mild. Large outbreaks can occur periodically resulting in significant morbidity. OBJECTIVES: This study aimed at analyzing the available influenza C clinical samples from two widely separated states of Australia, collected over a 7-year period and to compare them with influenza C viruses detected in other parts of the world in recent years. PATIENTS/METHODS: Between 2008 and 2014, 86 respiratory samples that were influenza C positive were collected from subjects with influenza-like illness living in the states of Victoria and Western Australia. A battery of other respiratory viruses were also tested for in these influenza C-positive samples. Virus isolation was attempted on all of these clinical samples, and gene sequencing was performed on all influenza C-positive cultures. RESULTS AND CONCLUSIONS: Detections of influenza C in respiratory samples were sporadic in most years studied, but higher rates of infection occurred in 2012 and 2014. Many of the patients with influenza C had coinfections with other respiratory pathogens. Phylogenetic analysis of the full-length hemagglutinin-esterase-fusion (HE) gene found that most of the viruses grouped in the C/Sao Paulo/378/82 clade with the remainder grouping in the C/Kanagawa/1/76 clade.
LA  - English
PB  - WILEY
T1  - Influenza C infections in Western Australia and Victoria from 2008 to 2014
DO  - 10.1111/irv.12402
IS  - Influenza and Other Respiratory Viruses
VL  - 10
IS  - 6
SP  - 455-461
L1  - /bitstream/handle/11343/257904/PMC5059950.pdf?sequence=1&isAllowed=y
ER  -