TY - JOUR AU - Sachdev, PS AU - Lipnicki, DM AU - Kochan, NA AU - Crawford, JD AU - Thalamuthu, A AU - Andrews, G AU - Brayne, C AU - Matthews, FE AU - Stephan, BCM AU - Lipton, RB AU - Katz, MJ AU - Ritchie, K AU - Carriere, I AU - Ancelin, M-L AU - Lam, LCW AU - Wong, CHY AU - Fung, AWT AU - Guaita, A AU - Vaccaro, R AU - Davin, A AU - Ganguli, M AU - Dodge, H AU - Hughes, T AU - Anstey, KJ AU - Cherbuin, N AU - Butterworth, P AU - Ng, TP AU - Gao, Q AU - Reppermund, S AU - Brodaty, H AU - Schupf, N AU - Manly, J AU - Stern, Y AU - Lobo, A AU - Lopez-Anton, R AU - Santabarbara, J Y2 - 2020/12/22 Y1 - 2015/11/05 SN - 1932-6203 UR - http://hdl.handle.net/11343/258170 AB - BACKGROUND: Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI). METHODS: Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment. RESULTS: The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01). CONCLUSION: Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally. LA - English PB - PUBLIC LIBRARY SCIENCE T1 - The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration DO - 10.1371/journal.pone.0142388 IS - PLoS One VL - 10 IS - 11 L1 - /bitstream/handle/11343/258170/PMC4634954.pdf?sequence=1&isAllowed=y ER -