TY - JOUR AU - Onofrillo, C AU - Galbiati, A AU - Montanaro, L AU - Derenzini, M Y2 - 2020/12/22 Y1 - 2017/01/17 SN - 1949-2553 UR - http://hdl.handle.net/11343/258203 AB - Pre-ribosomal complex RPL5/RPL11/5S rRNA (5S RNP) is considered the central MDM2 inhibitory complex that control p53 stabilization during ribosome biogenesis inhibition. Despite its role is well defined, the dynamic of 5S RNP assembly still requires further characterization. In the present work, we report that MDM2 inhibition is dependent by a pre-existing population of 5S rRNA. LA - English PB - IMPACT JOURNALS LLC T1 - The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition DO - 10.18632/oncotarget.13833 IS - Oncotarget VL - 8 IS - 3 SP - 4257-4267 L1 - /bitstream/handle/11343/258203/PMC5354829.pdf?sequence=1&isAllowed=y ER -