TY  - JOUR
AU  - de la Fuente, AG
AU  - Errea, O
AU  - van Wijngaarden, P
AU  - Gonzalez, GA
AU  - Kerninon, C
AU  - Jarjour, AA
AU  - Lewis, HJ
AU  - Jones, CA
AU  - Nait-Oumesmar, B
AU  - Zhao, C
AU  - Huang, JK
AU  - Ffrench-Constant, C
AU  - Franklin, RJM
Y2  - 2020/12/22
Y1  - 2015/12/07
SN  - 0021-9525
UR  - http://hdl.handle.net/11343/258271
AB  - The mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor cells (OPCs) into mature OLGs are key to understanding myelination and remyelination. Signaling via the retinoid X receptor γ (RXR-γ) has been shown to be a positive regulator of OPC differentiation. However, the nuclear receptor (NR) binding partner of RXR-γ has not been established. In this study we show that RXR-γ binds to several NRs in OPCs and OLGs, one of which is vitamin D receptor (VDR). Using pharmacological and knockdown approaches we show that RXR-VDR signaling induces OPC differentiation and that VDR agonist vitamin D enhances OPC differentiation. We also show expression of VDR in OLG lineage cells in multiple sclerosis. Our data reveal a role for vitamin D in the regenerative component of demyelinating disease and identify a new target for remyelination medicines.
LA  - English
PB  - ROCKEFELLER UNIV PRESS
T1  - Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation
DO  - 10.1083/jcb.201505119
IS  - The Journal of Cell Biology
VL  - 211
IS  - 5
SP  - 975-985
OP  - 628928
L1  - /bitstream/handle/11343/258271/PMC4674280.pdf?sequence=1&isAllowed=y
ER  -