TY - JOUR AU - Vandenberg, CJ AU - Motoyama, N AU - Cory, S Y2 - 2020/12/22 Y1 - 2016/01/01 SN - 2041-4889 UR - http://hdl.handle.net/11343/258278 AB - This study demonstrates, for the first time, that loss of a single forkhead box class O (FoxO) transcription factor, can promote lymphomagenesis. Using two different mouse models, we show that FoxO3 has a significant tumour-suppressor function in the context of Myc-driven lymphomagenesis. Loss of FoxO3 significantly accelerated myeloid tumorigenesis in vavP-MYC10 transgenic mice and B lymphomagenesis in Eμ-myc transgenic mice. Tumour analysis indicated that the selective pressure for mutation of the p53 pathway during Eμ-myc lymphomagenesis was not altered. Frank tumours were preceded by elevated macrophage numbers in FoxO3(-/-) vavP-MYC10 mice but, surprisingly, pre-B-cell numbers were relatively normal in healthy young FoxO3(-/-)Eμ-myc mice. In vitro assays revealed enhanced survival capacity of Myc-driven cells lacking FoxO3, but no change in cell cycling was detected. The loss of FoxO3 may also be affecting other tumour-suppressive functions for which FoxO1/4 cannot fully compensate. LA - English PB - NATURE PUBLISHING GROUP T1 - FoxO3 suppresses Myc-driven lymphomagenesis DO - 10.1038/cddis.2015.396 IS - Cell Death and Disease VL - 7 IS - 1 L1 - /bitstream/handle/11343/258278/PMC4816178.pdf?sequence=1&isAllowed=y ER -