TY  - JOUR
AU  - Vandenberg, CJ
AU  - Motoyama, N
AU  - Cory, S
Y2  - 2020/12/22
Y1  - 2016/01/01
SN  - 2041-4889
UR  - http://hdl.handle.net/11343/258278
AB  - This study demonstrates, for the first time, that loss of a single forkhead box class O (FoxO) transcription factor, can promote lymphomagenesis. Using two different mouse models, we show that FoxO3 has a significant tumour-suppressor function in the context of Myc-driven lymphomagenesis. Loss of FoxO3 significantly accelerated myeloid tumorigenesis in vavP-MYC10 transgenic mice and B lymphomagenesis in Eμ-myc transgenic mice. Tumour analysis indicated that the selective pressure for mutation of the p53 pathway during Eμ-myc lymphomagenesis was not altered. Frank tumours were preceded by elevated macrophage numbers in FoxO3(-/-) vavP-MYC10 mice but, surprisingly, pre-B-cell numbers were relatively normal in healthy young FoxO3(-/-)Eμ-myc mice. In vitro assays revealed enhanced survival capacity of Myc-driven cells lacking FoxO3, but no change in cell cycling was detected. The loss of FoxO3 may also be affecting other tumour-suppressive functions for which FoxO1/4 cannot fully compensate.
LA  - English
PB  - NATURE PUBLISHING GROUP
T1  - FoxO3 suppresses Myc-driven lymphomagenesis
DO  - 10.1038/cddis.2015.396
IS  - Cell Death and Disease
VL  - 7
IS  - 1
L1  - /bitstream/handle/11343/258278/PMC4816178.pdf?sequence=1&isAllowed=y
ER  -