TY  - JOUR
AU  - KEMP, DJ
AU  - ADAMS, JM
AU  - MOTTRAM, PL
AU  - THOMAS, WR
AU  - WALKER, ID
AU  - MILLER, J
Y2  - 2020/12/22
Y1  - 1982/01/01
SN  - 0022-1007
UR  - http://hdl.handle.net/11343/258364
AB  - Expression of VH-coded mRNA molecules in T cells, antigen-specific T cell lines, or T cell hybridomas was not detected using four different VH DNA probes under conditions that permitted cross-hybridization between distantly related VH genes. In contrast, VH gene expression was readily detected in two B cell lymphomas and in splenic B cells. Less than one molecule per cell of RNA, exactly complementary to the DNA probes used, would have been detected in these T cell populations. The results thus seriously question the proposition that T cells use the B cell VH repertoire to code for antigen receptors.
LA  - English
PB  - ROCKEFELLER UNIV PRESS
T1  - A SEARCH FOR MESSENGER-RNA MOLECULES BEARING IMMUNOGLOBULIN VH NUCLEOTIDE-SEQUENCES IN T-CELLS
DO  - 10.1084/jem.156.6.1848
IS  - Journal of Experimental Medicine
VL  - 156
IS  - 6
SP  - 1848-1853
L1  - /bitstream/handle/11343/258364/PMC2186877.pdf?sequence=1&isAllowed=y
ER  -