TY  - JOUR
AU  - Winney, B
AU  - Boumertit, A
AU  - Day, T
AU  - Davison, D
AU  - Echeta, C
AU  - Evseeva, I
AU  - Hutnik, K
AU  - Leslie, S
AU  - Nicodemus, K
AU  - Royrvik, EC
AU  - Tonks, S
AU  - Yang, X
AU  - Cheshire, J
AU  - Longley, P
AU  - Mateos, P
AU  - Groom, A
AU  - Relton, C
AU  - Bishop, DT
AU  - Black, K
AU  - Northwood, E
AU  - Parkinson, L
AU  - Frayling, TM
AU  - Steele, A
AU  - Sampson, JR
AU  - King, T
AU  - Dixon, R
AU  - Middleton, D
AU  - Jennings, B
AU  - Bowden, R
AU  - Donnelly, P
AU  - Bodmer, W
Y2  - 2021/02/03
Y1  - 2012/02/01
SN  - 1018-4813
UR  - http://hdl.handle.net/11343/258967
AB  - There is a great deal of interest in a fine-scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current generation of genome-wide association studies, it is likely to have a significant part in the next generation of studies designed to search for rare variants. A powerful way of detecting such structure is to control and document carefully the provenance of the samples involved. In this study, we describe the collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK-control population that can be used as a resource by the research community, as well as providing a fine-scale genetic information on the British population. So far, some 4000 samples have been collected, the majority of which fit the criteria of coming from a rural area and having all four grandparents from approximately the same area. Analysis of the first 3865 samples that have been geocoded indicates that 75% have a mean distance between grandparental places of birth of 37.3 km, and that about 70% of grandparental places of birth can be classed as rural. Preliminary genotyping of 1057 samples demonstrates the value of these samples for investigating a fine-scale population structure within the UK, and shows how this can be enhanced by the use of surnames.
LA  - English
PB  - NATURE PUBLISHING GROUP
T1  - People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population
DO  - 10.1038/ejhg.2011.127
IS  - European Journal of Human Genetics
VL  - 20
IS  - 2
SP  - 203-210
L1  - /bitstream/handle/11343/258967/PMC3260910.pdf?sequence=1&isAllowed=y
ER  -