TY  - JOUR
AU  - Papadimitriou, ID
AU  - Lucia, A
AU  - Pitsiladis, YP
AU  - Pushkarev, VP
AU  - Dyatlov, DA
AU  - Orekhov, EF
AU  - Artioli, GG
AU  - Guilherme, JPLF
AU  - Lancha, AH
AU  - Gineviciene, V
AU  - Cieszczyk, P
AU  - Maciejewska-Karlowska, A
AU  - Sawczuk, M
AU  - Muniesa, CA
AU  - Kouvatsi, A
AU  - Massidda, M
AU  - Calo, CM
AU  - Garton, F
AU  - Houweling, PJ
AU  - Wang, G
AU  - Austin, K
AU  - Druzhevskaya, AM
AU  - Astratenkova, IV
AU  - Ahmetov, II
AU  - Bishop, DJ
AU  - North, KN
AU  - Eynon, N
Y2  - 2021/02/03
Y1  - 2016/04/13
SN  - 1471-2164
UR  - http://hdl.handle.net/11343/258988
AB  - BACKGROUND: To date, studies investigating the association between ACTN3 R577X and ACE I/D gene variants and elite sprint/power performance have been limited by small cohorts from mixed sport disciplines, without quantitative measures of performance. AIM: To examine the association between these variants and sprint time in elite athletes. METHODS: We collected a total of 555 best personal 100-, 200-, and 400-m times of 346 elite sprinters in a large cohort of elite Caucasian or African origin sprinters from 10 different countries. Sprinters were genotyped for ACTN3 R577X and ACE ID variants. RESULTS: On average, male Caucasian sprinters with the ACTN3 577RR or the ACE DD genotype had faster best 200-m sprint time than their 577XX (21.19 ± 0.53 s vs. 21.86 ± 0.54 s, p = 0.016) and ACE II (21.33 ± 0.56 vs. 21.93 ± 0.67 sec, p = 0.004) counterparts and only one case of ACE II, and no cases of ACTN3 577XX, had a faster 200-m time than the 2012 London Olympics qualifying (vs. 12 qualified sprinters with 577RR or 577RX genotype). Caucasian sprinters with the ACE DD genotype had faster best 400-m sprint time than their ACE II counterparts (46.94 ± 1.19 s vs. 48.50 ± 1.07 s, p = 0.003). Using genetic models we found that the ACTN3 577R allele and ACE D allele dominant model account for 0.92 % and 1.48 % of sprint time variance, respectively. CONCLUSIONS: Despite sprint performance relying on many gene variants and environment, the % sprint time variance explained by ACE and ACTN3 is substantial at the elite level and might be the difference between a world record and only making the final.
LA  - English
PB  - BIOMED CENTRAL LTD
T1  - ACTN3 R577X and ACE I/D gene variants influence performance in elite sprinters: a multi-cohort study
DO  - 10.1186/s12864-016-2462-3
IS  - BMC Genomics
VL  - 17
IS  - 1
L1  - /bitstream/handle/11343/258988/PMC4831144.pdf?sequence=1&isAllowed=y
ER  -