TY  - JOUR
AU  - Lim, L
AU  - Sayers, CP
AU  - Goodman, CD
AU  - McFadden, GI
Y2  - 2021/02/04
Y1  - 2016/07/21
SN  - 1932-6203
UR  - http://hdl.handle.net/11343/259509
AB  - Apicoplasts are vestigial plastids in apicomplexan parasites like Plasmodium, the causative agent of malaria. Apicomplexan parasites are dependant on their apicoplasts for synthesis of various molecules that they are unable to scavenge in sufficient quantity from their host, which makes apicoplasts attractive drug targets. Proteins known as plastid phosphate translocators (pPTs) are embedded in the outer apicoplast membrane and are responsible for the import of carbon, energy and reducing power to drive anabolic synthesis in the organelle. We investigated how a pPT is targeted into the outer apicoplast membrane of the human malaria parasite P. falciparum. We showed that a transmembrane domain is likely to act as a recessed signal anchor to direct the protein into the endomembrane system, and that a tyrosine in the cytosolic N-terminus of the protein is essential for targeting, but one or more, as yet unidentified, factors are also essential to direct the protein into the outer apicoplast membrane.
LA  - English
PB  - PUBLIC LIBRARY SCIENCE
T1  - Targeting of a Transporter to the Outer Apicoplast Membrane in the Human Malaria Parasite Plasmodium falciparum
DO  - 10.1371/journal.pone.0159603
IS  - PLoS One
VL  - 11
IS  - 7
OP  - DP130103236
L1  - /bitstream/handle/11343/259509/PMC4956234.pdf?sequence=1&isAllowed=y
ER  -