TY  - JOUR
AU  - Yu, Y
AU  - Wang, C
AU  - Clare, S
AU  - Wang, J
AU  - Lee, S-C
AU  - Brandt, C
AU  - Burke, S
AU  - Lu, L
AU  - He, D
AU  - Jenkins, NA
AU  - Copeland, NG
AU  - Dougan, G
AU  - Liu, P
Y2  - 2021/02/05
Y1  - 2015/06/01
SN  - 0022-1007
UR  - http://hdl.handle.net/11343/260069
AB  - Group 2 innate lymphoid cells (ILCs), or ILC2s, are a subset of recently identified ILCs, which play important roles in innate immunity by producing type 2 effector cytokines. Several transcription factors have been found to have critical functions in the development of both ILC2s and T cells. We report here that Bcl11b, a transcription factor essential in T cell lineage commitment and maintenance, is specifically expressed in progenitors committed to the ILC2 lineage and is required for ILC2 development. The Bcl11b gene is expressed in ∼28% of ILC progenitors (ILCPs; common helper innate lymphoid progenitors or ILCPs expressing either ID2 or promyelocytic leukemia zinc finger, respectively). Both in vitro and in vivo, these Bcl11b-expressing early ILCPs generate only ILC2s. Inactivation of Bcl11b causes a complete loss of ILC2 development from hematopoietic progenitors, which is confirmed upon immune challenge with either papain administration or influenza virus infection.
LA  - English
PB  - ROCKEFELLER UNIV PRESS
T1  - The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development
DO  - 10.1084/jem.20142318
IS  - Journal of Experimental Medicine
VL  - 212
IS  - 6
SP  - 865-874
L1  - /bitstream/handle/11343/260069/PMC4451136.pdf?sequence=1&isAllowed=y
ER  -