TY  - JOUR
AU  - Cowley, MJ
AU  - Pinese, M
AU  - Kassahn, KS
AU  - Waddell, N
AU  - Pearson, JV
AU  - Grimmond, SM
AU  - Biankin, AV
AU  - Hautaniemi, S
AU  - Wu, J
Y2  - 2021/02/05
Y1  - 2012/01/01
SN  - 0305-1048
UR  - http://hdl.handle.net/11343/260132
AB  - The Protein Interaction Network Analysis (PINA) platform is a comprehensive web resource, which includes a database of unified protein-protein interaction data integrated from six manually curated public databases, and a set of built-in tools for network construction, filtering, analysis and visualization. The second version of PINA enhances its utility for studies of protein interactions at a network level, by including multiple collections of interaction modules identified by different clustering approaches from the whole network of protein interactions ('interactome') for six model organisms. All identified modules are fully annotated by enriched Gene Ontology terms, KEGG pathways, Pfam domains and the chemical and genetic perturbations collection from MSigDB. Moreover, a new tool is provided for module enrichment analysis in addition to simple query function. The interactome data are also available on the web site for further bioinformatics analysis. PINA is freely accessible at http://cbg.garvan.unsw.edu.au/pina/.
LA  - English
PB  - OXFORD UNIV PRESS
T1  - PINA v2.0: mining interactome modules
DO  - 10.1093/nar/gkr967
IS  - Nucleic Acids Research
VL  - 40
IS  - D1
SP  - D862-D865
L1  - /bitstream/handle/11343/260132/PMC3244997.pdf?sequence=1&isAllowed=y
ER  -