TY  - JOUR
AU  - Hajarizadeh, B
AU  - Grady, B
AU  - Page, K
AU  - Kim, AY
AU  - McGovern, BH
AU  - Cox, AL
AU  - Rice, TM
AU  - Sacks-Davis, R
AU  - Bruneau, J
AU  - Morris, M
AU  - Amin, J
AU  - Schinkel, J
AU  - Applegate, T
AU  - Maher, L
AU  - Hellard, M
AU  - Lloyd, AR
AU  - Prins, M
AU  - Dore, GJ
AU  - Grebely, J
Y2  - 2021/02/05
Y1  - 2015/04/02
SN  - 1932-6203
UR  - http://hdl.handle.net/11343/260179
AB  - BACKGROUND: Understanding the patterns of HCV RNA levels during acute hepatitis C virus (HCV) infection provides insights into immunopathogenesis and is important for vaccine design. This study evaluated patterns of HCV RNA levels and associated factors among individuals with acute infection. METHODS: Data were from an international collaboration of nine prospective cohorts of acute HCV (InC3 Study). Participants with well-characterized acute HCV infection (detected within three months post-infection and interval between the peak and subsequent HCV RNA levels ≤ 120 days) were categorised by a priori-defined patterns of HCV RNA levels: i) spontaneous clearance, ii) partial viral control with persistence (≥ 1 log IU/mL decline in HCV RNA levels following peak) and iii) viral plateau with persistence (increase or <1 log IU/mL decline in HCV RNA levels following peak). Factors associated with HCV RNA patterns were assessed using multinomial logistic regression. RESULTS: Among 643 individuals with acute HCV, 162 with well-characterized acute HCV were identified: spontaneous clearance (32%), partial viral control with persistence (27%), and viral plateau with persistence (41%). HCV RNA levels reached a high viraemic phase within two months following infection, with higher levels in the spontaneous clearance and partial viral control groups, compared to the viral plateau group (median: 6.0, 6.2, 5.3 log IU/mL, respectively; P = 0.018). In the two groups with persistence, Interferon lambda 3 (IFNL3) CC genotype was independently associated with partial viral control compared to viral plateau (adjusted odds ratio [AOR]: 2.75; 95%CI: 1.08, 7.02). In the two groups with viral control, female sex was independently associated with spontaneous clearance compared to partial viral control (AOR: 2.86; 95%CI: 1.04, 7.83). CONCLUSIONS: Among individuals with acute HCV, a spectrum of HCV RNA patterns is evident. IFNL3 CC genotype is associated with initial viral control, while female sex is associated with ultimate spontaneous clearance.
LA  - English
PB  - PUBLIC LIBRARY SCIENCE
T1  - Patterns of Hepatitis C Virus RNA Levels during Acute Infection: The InC3 Study
DO  - 10.1371/journal.pone.0122232
IS  - PLoS One
VL  - 10
IS  - 4
L1  - /bitstream/handle/11343/260179/PMC4383375.pdf?sequence=1&isAllowed=y
ER  -