TY  - JOUR
AU  - Kristjansson, S
AU  - McCutcheon, VV
AU  - Agrawal, A
AU  - Lynskey, MT
AU  - Conroy, E
AU  - Statham, DJ
AU  - Madden, PAF
AU  - Henders, AK
AU  - Todorov, AA
AU  - Bucholz, KK
AU  - Degenhardt, L
AU  - Martin, NG
AU  - Heath, AC
AU  - Nelson, EC
Y2  - 2021/02/05
Y1  - 2016/02/01
SN  - 2162-3279
UR  - http://hdl.handle.net/11343/260258
AB  - INTRODUCTION: Forms of childhood trauma tend to co-occur and are associated with increased risk for psychiatric and substance use disorders. Commonly used binary measures of trauma exposure have substantial limitations. METHODS: We performed multigroup confirmatory factor analysis (CFA), separately by sex, using data from the Childhood Trauma (CT) Study's sample of twins and siblings (N = 2594) to derive three first-order factors (childhood physical abuse, childhood sexual abuse, and parental partner abuse) and, as hypothesized, one higher order, childhood trauma factor (CTF) representing a measure of their common variance. RESULTS: CFA produced a good-fitting model in the CT Study; we replicated the model in the Comorbidity and Trauma (CAT) Study's sample (N = 1981) of opioid-dependent cases and controls. In both samples, first-order factors are moderately correlated (indicating they measure largely unique, but related constructs) and their loadings on the CTF suggest it provides a reasonable measure of their common variance. We examined the association of CTF score with risk for psychiatric and substance use disorders in these samples and the OZ-ALC GWAS sample (N = 1538) in which CT Study factor loadings were applied. We found that CTF scores are strongly associated with liability for psychiatric and substance use disorders in all three samples; estimates of risk are extremely consistent across samples. CONCLUSIONS: The CTF is a continuous, robust measure that captures the common variance across forms of childhood trauma and provides a means to estimate shared liability while avoiding multicollinearity.
LA  - English
PB  - JOHN WILEY & SONS INC
T1  - The variance shared across forms of childhood trauma is strongly associated with liability for psychiatric and substance use disorders
DO  - 10.1002/brb3.432
IS  - Brain and Behavior
VL  - 6
IS  - 2
L1  - /bitstream/handle/11343/260258/PMC4720689.pdf?sequence=1&isAllowed=y
ER  -