TY  - JOUR
AU  - McGuire, LI
AU  - Poleggi, A
AU  - Poggiolini, I
AU  - Suardi, S
AU  - Grznarova, K
AU  - Shi, S
AU  - de Vil, B
AU  - Sarros, S
AU  - Satoh, K
AU  - Cheng, K
AU  - Cramm, M
AU  - Fairfoul, G
AU  - Schmitz, M
AU  - Zerr, I
AU  - Cras, P
AU  - Equestre, M
AU  - Tagliavini, F
AU  - Atarashi, R
AU  - Knox, D
AU  - Collins, S
AU  - Haik, S
AU  - Parchi, P
AU  - Pocchiari, M
AU  - Green, A
Y2  - 2021/02/05
Y1  - 2016/07/01
SN  - 0364-5134
UR  - http://hdl.handle.net/11343/260379
AB  - Real-time quaking-induced conversion (RT-QuIC) has been proposed as a sensitive diagnostic test for sporadic Creutzfeldt-Jakob disease; however, before this assay can be introduced into clinical practice, its reliability and reproducibility need to be demonstrated. Two international ring trials were undertaken in which a set of 25 cerebrospinal fluid samples were analyzed by a total of 11 different centers using a range of recombinant prion protein substrates and instrumentation. The results show almost complete concordance between the centers and demonstrate that RT-QuIC is a suitably reliable and robust technique for clinical practice. Ann Neurol 2016;80:160-165.
LA  - English
PB  - WILEY-BLACKWELL
T1  - Cerebrospinal Fluid Real-Time Quaking-Induced Conversion Is a Robust and Reliable Test for Sporadic Creutzfeldt-Jakob Disease: An International Study
DO  - 10.1002/ana.24679
IS  - Annals of Neurology
VL  - 80
IS  - 1
SP  - 160-165
L1  - /bitstream/handle/11343/260379/PMC4982084.pdf?sequence=1&isAllowed=y
ER  -