TY  - JOUR
AU  - Wu, C
AU  - Wang, L
AU  - Fang, Z
AU  - Hu, Y
AU  - Chen, S
AU  - Sugawara, T
AU  - Ye, X
Y2  - 2021/02/05
Y1  - 2016/05/01
SN  - 1660-3397
UR  - http://hdl.handle.net/11343/260469
AB  - To elucidate the structure-antioxidant activity relationships of chitosan gallate (CG), a series of CG derivatives with different degrees of substitution (DS's) and molecular weights (MWs) were synthesized from chitosan (CS) and gallic acid (GA) via a free radical graft reaction. A higher MW led to a lower DS of CG. The structures of CG were characterized by FT-IR and ¹H NMR, and results showed that GA was mainly conjugated to the C-2 and C-6 positions of the CS chain. The antioxidant activity (the DPPH radical scavenging activity and reducing power) were enhanced with an increased DS and a decreased MW of CG. A correlation between antioxidant activities and the DS and MW of CG was also established. In addition, a suitable concentration (0~250 μg/mL) of CG with different MWs (32.78~489.32 kDa) and DS's (0~92.89 mg·GAE/g CG) has no cytotoxicity. These results should provide a guideline to the application of CG derivatives in food or pharmacology industries.
LA  - English
PB  - MDPI
T1  - The Effect of the Molecular Architecture on the Antioxidant Properties of Chitosan Gallate
DO  - 10.3390/md14050095
IS  - Marine Drugs
VL  - 14
IS  - 5
L1  - /bitstream/handle/11343/260469/PMC4882569.pdf?sequence=1&isAllowed=y
ER  -