TY  - JOUR
AU  - Sutherland, JS
AU  - Goldberg, GL
AU  - Hammett, MV
AU  - Uldrich, AP
AU  - Berzins, SP
AU  - Heng, TS
AU  - Blazar, BR
AU  - Millar, JL
AU  - Malin, MA
AU  - Chidgey, AP
AU  - Boyd, RL
Y2  - 2014/05/21
Y1  - 2005/08/15
SN  - 0022-1767
UR  - http://hdl.handle.net/11343/26141
AB  - The thymus undergoes age-related atrophy, coincident with increased circulating sex steroids from puberty. The impact of thymic atrophy is most profound in clinical conditions that cause a severe loss in peripheral T cells with the ability to regenerate adequate numbers of naive CD4+ T cells indirectly correlating with patient age. The present study demonstrates that androgen ablation results in the complete regeneration of the aged male mouse thymus, restoration of peripheral T cell phenotype and function and enhanced thymus regeneration following bone marrow transplantation. Importantly, this technique is also applicable to humans, with analysis of elderly males undergoing sex steroid ablation therapy for prostatic carcinoma, demonstrating an increase in circulating T cell numbers, particularly naive (TREC+) T cells. Collectively these studies represent a fundamentally new approach to treating immunodeficiency states in humans.
N1  - application/pdf
LA  - English
PB  - AMER ASSOC IMMUNOLOGISTS
KW  - Cellular Immunology; Immune System and Allergy
T1  - Activation of thymic regeneration in mice and humans following androgen blockade
DO  - 10.4049/jimmunol.175.4.2741
IS  - JOURNAL OF IMMUNOLOGY
VL  - 175
IS  - 4
SP  - 2741-2753
L1  - /bitstream/handle/11343/26141/115904_4946.pdf?sequence=1&isAllowed=n
ER  -