TY  - JOUR
AU  - Pratt, BF
AU  - O'Connor, DH
AU  - Lafont, BAP
AU  - Mankowski, JL
AU  - Fernandez, CS
AU  - Triastuti, R
AU  - Brooks, AG
AU  - Kent, SJ
AU  - Smith, MZ
Y2  - 2014/05/21
Y2  - 2006/09/21
Y2  - 2006/09/21
Y2  - 2006/09/21
Y2  - 2006/09/21
Y1  - 2006/12/01
SN  - 0093-7711
UR  - http://hdl.handle.net/11343/26333
AB  - Pigtail macaques (Macaca nemestrina) are an increasingly common primate model for the study of human AIDS. Major Histocompatibility complex (MHC) class I-restricted CD8(+) T cell responses are a critical part of the adaptive immune response to HIV-1 in humans and simian immunodeficiency virus (SIV) in macaques; however, MHC class I alleles have not yet been comprehensively characterized in pigtail macaques. The frequencies of ten previously defined alleles (four Mane-A and six Mane-B) were investigated in detail in 109 pigtail macaques using reference strand-mediated conformational analysis (RSCA). The macaques were derived from three separate breeding colonies in the USA, Indonesia and Australia, and allele frequencies were analysed within and between these groups. Mane-A*10, an allele that restricts the immunodominant SIV Gag epitope KP9, was the most common allele, present in 32.1% of the animals overall, with similar frequencies across the three cohorts. Additionally, RSCA identified a new allele (Mane-A*17) common to three Indonesian pigtail macaques responding to the same Gag CD8(+) T cell epitope. This broad characterization of common MHC class I alleles in more than 100 pigtail macaques further develops this animal model for the study of virus-specific CD8(+) T cell responses.
N1  - application/pdf
LA  - English
PB  - SPRINGER
KW  - Medical Virology ; Infectious Diseases
T1  - MHC class I allele frequencies in pigtail macaques of diverse origin
DO  - 10.1007/s00251-006-0164-8
IS  - IMMUNOGENETICS
VL  - 58
IS  - 12
SP  - 995-1001
L1  - /bitstream/handle/11343/26333/116108_5169.pdf?sequence=1&isAllowed=n
ER  -