TY  - JOUR
AU  - Chong, MMW
AU  - Cornish, AL
AU  - Darwiche, R
AU  - Stanley, EG
AU  - Purton, JF
AU  - Godfrey, DI
AU  - Hilton, DJ
AU  - Starr, R
AU  - Alexander, WS
AU  - Kay, TWH
Y2  - 2014/05/21
Y1  - 2003/04/01
SN  - 1074-7613
UR  - http://hdl.handle.net/11343/26381
AB  - To determine the tissue-specific functions of SOCS-1, mice were generated in which the SOCS-1 gene could be deleted in individual tissues. A reporter gene of SOCS-1 promoter activity was also inserted. Using the reporter, high SOCS-1 expression was found at the CD4(+)CD8(+) stage in thymocyte development. To investigate the function of this expression, the SOCS-1 gene was specifically deleted throughout the thymocyte/T/NKT cell compartment. Unlike SOCS-1(-/-) mice, these mice did not develop lethal multiorgan inflammation but developed multiple lymphoid abnormalities, including enhanced differentiation of thymocytes toward CD8(+) T cells and very high percentages of peripheral CD8(+) T cells with a memory phenotype (CD44(hi)CD25(lo)CD69(lo)). These phenotypes were found to correlate with hypersensitivity to the gamma-common family of cytokines.
N1  - application/pdf
LA  - English
PB  - CELL PRESS
KW  - Cellular Immunology; Immune System and Allergy
T1  - Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8(+) T cell differentiation
DO  - 10.1016/S1074-7613(03)00078-5
IS  - IMMUNITY
VL  - 18
IS  - 4
SP  - 475-487
L1  - /bitstream/handle/11343/26381/116171_5221.pdf?sequence=1&isAllowed=n
ER  -